Gene name: UBE2E1

Uniprot entry:

P51965

Protein names:

Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1)

Protein sequence:

1_MSDDD 6_ SRAST 11_ SSSSS 16_ SSSNQ 21_ QTEKE 26_ TNTPK 31_ KKESK 36_ VSMSK 41_ NSKLL 46_ STSAK 51_ RIQKE 56_ LADIT 61_ LDPPP 66_ NCSAG 71_ PKGDN 76_ IYEWR 81_ STILG 86_ PPGSV 91_ YEGGV 96_ FFLDI 101_ TFTPE 106_ YPFKP 111_ PKVTF 116_ RTRIY 121_ HCNIN 126_ SQGVI 131_ CLDIL 136_ KDNWS 141_ PALTI 146_ SKVLL 151_ SICSL 156_ LTDCN 161_ PADPL 166_ VGSIA 171_ TQYMT 176_ NRAEH 181_ DRMAR 186_QWTKR

Protein annotations

Protein functions:

1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Catalyzes monoubiquitination of other proteins in both an E3-dependent and E3-independent manner (PubMed:27237050)