4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (EC 2.4.1.152) (Fucosyltransferase 6) (Fucosyltransferase VI) (Fuc-TVI) (FucT-VI) (Galactoside 3-L-fucosyltransferase)
1_MDPLG 6_ PAKPQ 11_ WSWRC 16_ CLTTL 21_ LFQLL 26_ MAVCF 31_ FSYLR 36_ VSQDD 41_ PTVYP 46_ NGSRF 51_ PDSTG 56_ TPAHS 61_ IPLIL 66_ LWTWP 71_ FNKPI 76_ ALPRC 81_ SEMVP 86_ GTADC 91_ NITAD 96_ RKVYP 101_ QADAV 106_ IVHHR 111_ EVMYN 116_ PSAQL 121_ PRSPR 126_ RQGQR 131_ WIWFS 136_ MESPS 141_ HCWQL 146_ KAMDG 151_ YFNLT 156_ MSYRS 161_ DSDIF 166_ TPYGW 171_ LEPWS 176_ GQPAH 181_ PPLNL 186_ SAKTE 191_ LVAWA 196_ VSNWG 201_ PNSAR 206_ VRYYQ 211_ SLQAH 216_ LKVDV 221_ YGRSH 226_ KPLPQ 231_ GTMME 236_ TLSRY 241_ KFYLA 246_ FENSL 251_ HPDYI 256_ TEKLW 261_ RNALE 266_ AWAVP 271_ VVLGP 276_ SRSNY 281_ ERFLP 286_ PDAFI 291_ HVDDF 296_ QSPKD 301_ LARYL 306_ QELDK 311_ DHARY 316_ LSYFR 321_ WRETL 326_ RPRSF 331_ SWALA 336_ FCKAC 341_ WKLQE 346_ ESRYQ 351_TRGIA
1: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or a glycolipid-linked polylactosamines chain through an alpha-1,3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe(x)), Lewis X (Le(x)) and non sialylated VIM2 determinants (PubMed:10728707, PubMed:1339443, PubMed:1520296, PubMed:17604274, PubMed:29593094, PubMed:7650030, PubMed:9363434, PubMed:9451035). Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates in difucosylated sialyl Lewis x determinants (PubMed:1339443, PubMed:17604274). Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X (PubMed:10728707). Does not have activity towards type 1 ((Galbeta1-3GlcNAc)) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates (PubMed:1339443, PubMed:17604274, PubMed:9363434)
2: Does not have alpha(1,3)-fucosyltransferase activity