Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
1_MSTNE 6_ NANTP 11_ AARLH 16_ RFKNK 21_ GKDST 26_ EMRRR 31_ RIEVN 36_ VELRK 41_ AKKDD 46_ QMLKR 51_ RNVSS 56_ FPDDA 61_ TSPLQ 66_ ENRNN 71_ QGTVN 76_ WSVDD 81_ IVKGI 86_ NSSNV 91_ ENQLQ 96_ ATQAA 101_ RKLLS 106_ REKQP 111_ PIDNI 116_ IRAGL 121_ IPKFV 126_ SFLGR 131_ TDCSP 136_ IQFES 141_ AWALT 146_ NIASG 151_ TSEQT 156_ KAVVD 161_ GGAIP 166_ AFISL 171_ LASPH 176_ AHISE 181_ QAVWA 186_ LGNIA 191_ GDGSV 196_ FRDLV 201_ IKYGA 206_ VDPLL 211_ ALLAV 216_ PDMSS 221_ LACGY 226_ LRNLT 231_ WTLSN 236_ LCRNK 241_ NPAPP 246_ IDAVE 251_ QILPT 256_ LVRLL 261_ HHDDP 266_ EVLAD 271_ TCWAI 276_ SYLTD 281_ GPNER 286_ IGMVV 291_ KTGVV 296_ PQLVK 301_ LLGAS 306_ ELPIV 311_ TPALR 316_ AIGNI 321_ VTGTD 326_ EQTQV 331_ VIDAG 336_ ALAVF 341_ PSLLT 346_ NPKTN 351_ IQKEA 356_ TWTMS 361_ NITAG 366_ RQDQI 371_ QQVVN 376_ HGLVP 381_ FLVSV 386_ LSKAD 391_ FKTQK 396_ EAVWA 401_ VTNYT 406_ SGGTV 411_ EQIVY 416_ LVHCG 421_ IIEPL 426_ MNLLT 431_ AKDTK 436_ IILVI 441_ LDAIS 446_ NIFQA 451_ AEKLG 456_ ETEKL 461_ SIMIE 466_ ECGGL 471_ DKIEA 476_ LQNHE 481_ NESVY 486_ KASLS 491_ LIEKY 496_ FSVEE 501_ EEDQN 506_ VVPET 511_ TSEGY 516_ TFQVQ 521_DGAPG
1: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349)