Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]
1_MTTPG 6_ KENFR 11_ LKSYK 16_ NKSLN 21_ PDEMR 26_ RRREE 31_ EGLQL 36_ RKQKR 41_ EEQLF 46_ KRRNV 51_ ATAEE 56_ ETEEE 61_ VMSDG 66_ GFHEA 71_ QISNM 76_ EMAPG 81_ GVITS 86_ DMIEM 91_ IFSKS 96_ PEQQL 101_ SATQK 106_ FRKLL 111_ SKEPN 116_ PPIDE 121_ VISTP 126_ GVVAR 131_ FVEFL 136_ KRKEN 141_ CTLQF 146_ ESAWV 151_ LTNIA 156_ SGNSL 161_ QTRIV 166_ IQAGA 171_ VPIFI 176_ ELLSS 181_ EFEDV 186_ QEQAV 191_ WALGN 196_ IAGDS 201_ TMCRD 206_ YVLDC 211_ NILPP 216_ LLQLF 221_ SKQNR 226_ LTMTR 231_ NAVWA 236_ LSNLC 241_ RGKSP 246_ PPEFA 251_ KVSPC 256_ LNVLS 261_ WLLFV 266_ SDTDV 271_ LADAC 276_ WALSY 281_ LSDGP 286_ NDKIQ 291_ AVIDA 296_ GVCRR 301_ LVELL 306_ MHNDY 311_ KVVSP 316_ ALRAV 321_ GNIVT 326_ GDDIQ 331_ TQVIL 336_ NCSAL 341_ QSLLH 346_ LLSSP 351_ KESIK 356_ KEACW 361_ TISNI 366_ TAGNR 371_ AQIQT 376_ VIDAN 381_ IFPAL 386_ ISILQ 391_ TAEFR 396_ TRKEA 401_ AWAIT 406_ NATSG 411_ GSAEQ 416_ IKYLV 421_ ELGCI 426_ KPLCD 431_ LLTVM 436_ DSKIV 441_ QVALN 446_ GLENI 451_ LRLGE 456_ QEAKR 461_ NGTGI 466_ NPYCA 471_ LIEEA 476_ YGLDK 481_ IEFLQ 486_ SHENQ 491_ EIYQK 496_ AFDLI 501_ EHYFG 506_ TEDED 511_ SSIAP 516_ QVDLN 521_ QQQYI 526_ FQQCE 531_APMEG
1: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:27713473, PubMed:7892216, PubMed:8692858). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:27713473, PubMed:7892216, PubMed:8692858). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:27713473, PubMed:7892216). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:7892216). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:7892216). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA2 and Transportin-1/TNPO1 (PubMed:35446349)
2: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS