Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
1_MAPPS 6_ EETPL 11_ IPQRS 16_ CSLLS 21_ TEAGA 26_ LHVLL 31_ PARGP 36_ GPPQR 41_ LSFSF 46_ GDHLA 51_ EDLCV 56_ QAAKA 61_ SGILP 66_ VYHSL 71_ FALAT 76_ EDLSC 81_ WFPPS 86_ HIFSV 91_ EDAST 96_ QVLLY 101_ RIRFY 106_ FPNWF 111_ GLEKC 116_ HRFGL 121_ RKDLA 126_ SAILD 131_ LPVLE 136_ HLFAQ 141_ HRSDL 146_ VSGRL 151_ PVGLS 156_ LKEQG 161_ ECLSL 166_ AVLDL 171_ ARMAR 176_ EQAQR 181_ PGELL 186_ KTVSY 191_ KACLP 196_ PSLRD 201_ LIQGL 206_ SFVTR 211_ RRIRR 216_ TVRRA 221_ LRRVA 226_ ACQAD 231_ RHSLM 236_ AKYIM 241_ DLERL 246_ DPAGA 251_ AETFH 256_ VGLPG 261_ ALGGH 266_ DGLGL 271_ LRVAG 276_ DGGIA 281_ WTQGE 286_ QEVLQ 291_ PFCDF 296_ PEIVD 301_ ISIKQ 306_ APRVG 311_ PAGEH 316_ RLVTV 321_ TRTDN 326_ QILEA 331_ EFPGL 336_ PEALS 341_ FVALV 346_ DGYFR 351_ LTTDS 356_ QHFFC 361_ KEVAP 366_ PRLLE 371_ EVAEQ 376_ CHGPI 381_ TLDFA 386_ INKLK 391_ TGGSR 396_ PGSYV 401_ LRRSP 406_ QDFDS 411_ FLLTV 416_ CVQNP 421_ LGPDY 426_ KGCLI 431_ RRSPT 436_ GTFLL 441_ VGLSR 446_ PHSSL 451_ RELLA 456_ TCWDG 461_ GLHVD 466_ GVAVT 471_ LTSCC 476_ IPRPK 481_ EKSNL 486_ IVVQR 491_ GHSPP 496_ TSSLV 501_ QPQSQ 506_ YQLSQ 511_ MTFHK 516_ IPADS 521_ LEWHE 526_ NLGHG 531_ SFTKI 536_ YRGCR 541_ HEVVD 546_ GEARK 551_ TEVLL 556_ KVMDA 561_ KHKNC 566_ MESFL 571_ EAASL 576_ MSQVS 581_ YRHLV 586_ LLHGV 591_ CMAGD 596_ STMVQ 601_ EFVHL 606_ GAIDM 611_ YLRKR 616_ GHLVP 621_ ASWKL 626_ QVVKQ 631_ LAYAL 636_ NYLED 641_ KGLPH 646_ GNVSA 651_ RKVLL 656_ AREGA 661_ DGSPP 666_ FIKLS 671_ DPGVS 676_ PAVLS 681_ LEMLT 686_ DRIPW 691_ VAPEC 696_ LREAQ 701_ TLSLE 706_ ADKWG 711_ FGATV 716_ WEVFS 721_ GVTMP 726_ ISALD 731_ PAKKL 736_ QFYED 741_ RQQLP 746_ APKWT 751_ ELALL 756_ IQQCM 761_ AYEPV 766_ QRPSF 771_ RAVIR 776_ DLNSL 781_ ISSDY 786_ ELLSD 791_ PTPGA 796_ LAPRD 801_ GLWNG 806_ AQLYA 811_ CQDPT 816_ IFEER 821_ HLKYI 826_ SQLGK 831_ GNFGS 836_ VELCR 841_ YDPLG 846_ DNTGA 851_ LVAVK 856_ QLQHS 861_ GPDQQ 866_ RDFQR 871_ EIQIL 876_ KALHS 881_ DFIVK 886_ YRGVS 891_ YGPGR 896_ QSLRL 901_ VMEYL 906_ PSGCL 911_ RDFLQ 916_ RHRAR 921_ LDASR 926_ LLLYS 931_ SQICK 936_ GMEYL 941_ GSRRC 946_ VHRDL 951_ AARNI 956_ LVESE 961_ AHVKI 966_ ADFGL 971_ AKLLP 976_ LDKDY 981_ YVVRE 986_ PGQSP 991_ IFWYA 996_ PESLS 1001_ DNIFS 1006_ RQSDV 1011_ WSFGV 1016_ VLYEL 1021_ FTYCD 1026_ KSCSP 1031_ SAEFL 1036_ RMMGC 1041_ ERDVP 1046_ ALCRL 1051_ LELLE 1056_ EGQRL 1061_ PAPPA 1066_ CPAEV 1071_ HELMK 1076_ LCWAP 1081_ SPQDR 1086_ PSFSA 1091_ LGPQL 1096_ DMLWS 1101_ GSRGC 1106_ ETHAF 1111_ TAHPE 1116_GKHHS
1: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion