Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon)
1_MEAER 6_ RPAPG 11_ SPSEG 16_ LFADG 21_ HLILW 26_ TLCSV 31_ LLPVF 36_ ITFWC 41_ SLQRS 46_ RRQLH 51_ RRDIF 56_ RKSKH 61_ GWRDT 66_ DLFSQ 71_ PTYCC 76_ VCAQH 81_ ILQGA 86_ FCDCC 91_ GLRVD 96_ EGCLR 101_ KADKR 106_ FQCKE 111_ IMLKN 116_ DTKVL 121_ DAMPH 126_ HWIRG 131_ NVPLC 136_ SYCMV 141_ CKQQC 146_ GCQPK 151_ LCDYR 156_ CIWCQ 161_ KTVHD 166_ ECMKN 171_ SLKNE 176_ KCDFG 181_ EFKNL 186_ IIPPS 191_ YLTSI 196_ NQMRK 201_ DKKTD 206_ YEVLA 211_ SKLGK 216_ QWTPL 221_ IILAN 226_ SRSGT 231_ NMGEG 236_ LLGEF 241_ RILLN 246_ PVQVF 251_ DVTKT 256_ PPIKA 261_ LQLCT 266_ LLPYY 271_ SARVL 276_ VCGGD 281_ GTVGW 286_ VLDAV 291_ DDMKI 296_ KGQEK 301_ YIPQV 306_ AVLPL 311_ GTGND 316_ LSNTL 321_ GWGTG 326_ YAGEI 331_ PVAQV 336_ LRNVM 341_ EADGI 346_ KLDRW 351_ KVQVT 356_ NKGYY 361_ NLRKP 366_ KEFTM 371_ NNYFS 376_ VGPDA 381_ LMALN 386_ FHAHR 391_ EKAPS 396_ LFSSR 401_ ILNKA 406_ VYLFY 411_ GTKDC 416_ LVQEC 421_ KDLNK 426_ KVELE 431_ LDGER 436_ VALPS 441_ LEGII 446_ VLNIG 451_ YWGGG 456_ CRLWE 461_ GMGDE 466_ TYPLA 471_ RHDDG 476_ LLEVV 481_ GVYGS 486_ FHCAQ 491_ IQVKL 496_ ANPFR 501_ IGQAH 506_ TVRLI 511_ LKCSM 516_ MPMQV 521_ DGEPW 526_ AQGPC 531_ TVTIT 536_ HKTHA 541_ MMLYF 546_ SGEQT 551_ DDDIS 556_ STSDQ 561_EDIKA
1: Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:19744926, PubMed:21477596, PubMed:22108654, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:15544348, PubMed:8626589). Also plays an important role in the biosynthesis of complex lipids (PubMed:8626589). Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:19744926, PubMed:22108654, PubMed:23274426). Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (PubMed:22108654)