Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
1_MAEQE 6_ PTAEQ 11_ LAQIA 16_ AENEE 21_ DEHSV 26_ NYKPP 31_ AQKSI 36_ QEIQE 41_ LDKDD 46_ ESLRK 51_ YKEAL 56_ LGRVA 61_ VSADP 66_ NVPNV 71_ VVTGL 76_ TLVCS 81_ SAPGP 86_ LELDL 91_ TGDLE 96_ SFKKQ 101_ SFVLK 106_ EGVEY 111_ RIKIS 116_ FRVNR 121_ EIVSG 126_ MKYIQ 131_ HTYRK 136_ GVKID 141_ KTDYM 146_ VGSYG 151_ PRAEE 156_ YEFLT 161_ PVEEA 166_ PKGML 171_ ARGSY 176_ SIKSR 181_ FTDDD 186_ KTDHL 191_ SWEWN 196_LTIKK
1: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1