Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)
1_MIPCR 6_ AALTF 11_ ARCLI 16_ RRKIV 21_ TLDSL 26_ EDTKL 31_ CRCLS 36_ TMDLI 41_ ALGVG 46_ STLGA 51_ GVYVL 56_ AGEVA 61_ KADSG 66_ PSIVV 71_ SFLIA 76_ ALASV 81_ MAGLC 86_ YAEFG 91_ ARVPK 96_ TGSAY 101_ LYTYV 106_ TVGEL 111_ WAFIT 116_ GWNLI 121_ LSYVI 126_ GTSSV 131_ ARAWS 136_ GTFDE 141_ LLSKQ 146_ IGQFL 151_ RTYFR 156_ MNYTG 161_ LAEYP 166_ DFFAV 171_ CLILL 176_ LAGLL 181_ SFGVK 186_ ESAWV 191_ NKVFT 196_ AVNIL 201_ VLLFV 206_ MVAGF 211_ VKGNV 216_ ANWKI 221_ SEEFL 226_ KNISA 231_ SAREP 236_ PSENG 241_ TSIYG 246_ AGGFM 251_ PYGFT 256_ GTLAG 261_ AATCF 266_ YAFVG 271_ FDCIA 276_ TTGEE 281_ VRNPQ 286_ KAIPI 291_ GIVTS 296_ LLVCF 301_ MAYFG 306_ VSAAL 311_ TLMMP 316_ YYLLD 321_ EKSPL 326_ PVAFE 331_ YVGWG 336_ PAKYV 341_ VAAGS 346_ LCALS 351_ TSLLG 356_ SIFPM 361_ PRVIY 366_ AMAED 371_ GLLFK 376_ CLAQI 381_ NSKTK 386_ TPIIA 391_ TLSSG 396_ AVAAL 401_ MAFLF 406_ DLKAL 411_ VDMMS 416_ IGTLM 421_ AYSLV 426_ AACVL 431_ ILRYQ 436_ PGLSY 441_ DQPKC 446_ SPEKD 451_ GLGSS 456_ PRVTS 461_ KSESQ 466_ VTMLQ 471_ RQGFS 476_ MRTLF 481_ CPSLL 486_ PTQQS 491_ ASLVS 496_ FLVGF 501_ LAFLV 506_ LGLSV 511_ LTTYG 516_ VHAIT 521_ RLEAW 526_ SLALL 531_ ALFLV 536_ LFVAI 541_ VLTIW 546_ RQPQN 551_ QQKVA 556_ FMVPF 561_ LPFLP 566_ AFSIL 571_ VNIYL 576_ MVQLS 581_ ADTWV 586_ RFSIW 591_ MAIGF 596_ LIYFS 601_ YGIRH 606_ SLEGH 611_ LRDEN 616_ NEEDA 621_ YPDNV 626_ HAAAE 631_ EKSAI 636_ QANDH 641_ HPRNL 646_ SSPFI 651_FHEKT
1: Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:28684763, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity)
2: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2
3: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine)