Signal transducer and activator of transcription 2 (p113)
1_MAQWE 6_ MLQNL 11_ DSPFQ 16_ DQLHQ 21_ LYSHS 26_ LLPVD 31_ IRQYL 36_ AVWIE 41_ DQNWQ 46_ EAALG 51_ SDDSK 56_ ATMLF 61_ FHFLD 66_ QLNYE 71_ CGRCS 76_ QDPES 81_ LLLQH 86_ NLRKF 91_ CRDIQ 96_ PFSQD 101_ PTQLA 106_ EMIFN 111_ LLLEE 116_ KRILI 121_ QAQRA 126_ QLEQG 131_ EPVLE 136_ TPVES 141_ QQHEI 146_ ESRIL 151_ DLRAM 156_ MEKLV 161_ KSISQ 166_ LKDQQ 171_ DVFCF 176_ RYKIQ 181_ AKGKT 186_ PSLDP 191_ HQTKE 196_ QKILQ 201_ ETLNE 206_ LDKRR 211_ KEVLD 216_ ASKAL 221_ LGRLT 226_ TLIEL 231_ LLPKL 236_ EEWKA 241_ QQQKA 246_ CIRAP 251_ IDHGL 256_ EQLET 261_ WFTAG 266_ AKLLF 271_ HLRQL 276_ LKELK 281_ GLSCL 286_ VSYQD 291_ DPLTK 296_ GVDLR 301_ NAQVT 306_ ELLQR 311_ LLHRA 316_ FVVET 321_ QPCMP 326_ QTPHR 331_ PLILK 336_ TGSKF 341_ TVRTR 346_ LLVRL 351_ QEGNE 356_ SLTVE 361_ VSIDR 366_ NPPQL 371_ QGFRK 376_ FNILT 381_ SNQKT 386_ LTPEK 391_ GQSQG 396_ LIWDF 401_ GYLTL 406_ VEQRS 411_ GGSGK 416_ GSNKG 421_ PLGVT 426_ EELHI 431_ ISFTV 436_ KYTYQ 441_ GLKQE 446_ LKTDT 451_ LPVVI 456_ ISNMN 461_ QLSIA 466_ WASVL 471_ WFNLL 476_ SPNLQ 481_ NQQFF 486_ SNPPK 491_ APWSL 496_ LGPAL 501_ SWQFS 506_ SYVGR 511_ GLNSD 516_ QLSML 521_ RNKLF 526_ GQNCR 531_ TEDPL 536_ LSWAD 541_ FTKRE 546_ SPPGK 551_ LPFWT 556_ WLDKI 561_ LELVH 566_ DHLKD 571_ LWNDG 576_ RIMGF 581_ VSRSQ 586_ ERRLL 591_ KKTMS 596_ GTFLL 601_ RFSES 606_ SEGGI 611_ TCSWV 616_ EHQDD 621_ DKVLI 626_ YSVQP 631_ YTKEV 636_ LQSLP 641_ LTEII 646_ RHYQL 651_ LTEEN 656_ IPENP 661_ LRFLY 666_ PRIPR 671_ DEAFG 676_ CYYQE 681_ KVNLQ 686_ ERRKY 691_ LKHRL 696_ IVVSN 701_ RQVDE 706_ LQQPL 711_ ELKPE 716_ PELES 721_ LELEL 726_ GLVPE 731_ PELSL 736_ DLEPL 741_ LKAGL 746_ DLGPE 751_ LESVL 756_ ESTLE 761_ PVIEP 766_ TLCMV 771_ SQTVP 776_ EPDQG 781_ PVSQP 786_ VPEPD 791_ LPCDL 796_ RHLNT 801_ EPMEI 806_ FRNCV 811_ KIEEI 816_ MPNGD 821_ PLLAG 826_ QNTVD 831_ EVYVS 836_ RPSHF 841_ YTDGP 846_LMPSD
1: Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188)