DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)
1_MSRQS 6_ TLYSF 11_ FPKSP 16_ ALSDA 21_ NKASA 26_ RASRE 31_ GGRAA 36_ AAPGA 41_ SPSPG 46_ GDAAW 51_ SEAGP 56_ GPRPL 61_ ARSAS 66_ PPKAK 71_ NLNGG 76_ LRRSV 81_ APAAP 86_ TSCDF 91_ SPGDL 96_ VWAKM 101_ EGYPW 106_ WPCLV 111_ YNHPF 116_ DGTFI 121_ REKGK 126_ SVRVH 131_ VQFFD 136_ DSPTR 141_ GWVSK 146_ RLLKP 151_ YTGSK 156_ SKEAQ 161_ KGGHF 166_ YSAKP 171_ EILRA 176_ MQRAD 181_ EALNK 186_ DKIKR 191_ LELAV 196_ CDEPS 201_ EPEEE 206_ EEMEV 211_ GTTYV 216_ TDKSE 221_ EDNEI 226_ ESEEE 231_ VQPKT 236_ QGSRR 241_ SSRQI 246_ KKRRV 251_ ISDSE 256_ SDIGG 261_ SDVEF 266_ KPDTK 271_ EEGSS 276_ DEISS 281_ GVGDS 286_ ESEGL 291_ NSPVK 296_ VARKR 301_ KRMVT 306_ GNGSL 311_ KRKSS 316_ RKETP 321_ SATKQ 326_ ATSIS 331_ SETKN 336_ TLRAF 341_ SAPQN 346_ SESQA 351_ HVSGG 356_ GDDSS 361_ RPTVW 366_ YHETL 371_ EWLKE 376_ EKRRD 381_ EHRRR 386_ PDHPD 391_ FDAST 396_ LYVPE 401_ DFLNS 406_ CTPGM 411_ RKWWQ 416_ IKSQN 421_ FDLVI 426_ CYKVG 431_ KFYEL 436_ YHMDA 441_ LIGVS 446_ ELGLV 451_ FMKGN 456_ WAHSG 461_ FPEIA 466_ FGRYS 471_ DSLVQ 476_ KGYKV 481_ ARVEQ 486_ TETPE 491_ MMEAR 496_ CRKMA 501_ HISKY 506_ DRVVR 511_ REICR 516_ IITKG 521_ TQTYS 526_ VLEGD 531_ PSENY 536_ SKYLL 541_ SLKEK 546_ EEDSS 551_ GHTRA 556_ YGVCF 561_ VDTSL 566_ GKFFI 571_ GQFSD 576_ DRHCS 581_ RFRTL 586_ VAHYP 591_ PVQVL 596_ FEKGN 601_ LSKET 606_ KTILK 611_ SSLSC 616_ SLQEG 621_ LIPGS 626_ QFWDA 631_ SKTLR 636_ TLLEE 641_ EYFRE 646_ KLSDG 651_ IGVML 656_ PQVLK 661_ GMTSE 666_ SDSIG 671_ LTPGE 676_ KSELA 681_ LSALG 686_ GCVFY 691_ LKKCL 696_ IDQEL 701_ LSMAN 706_ FEEYI 711_ PLDSD 716_ TVSTT 721_ RSGAI 726_ FTKAY 731_ QRMVL 736_ DAVTL 741_ NNLEI 746_ FLNGT 751_ NGSTE 756_ GTLLE 761_ RVDTC 766_ HTPFG 771_ KRLLK 776_ QWLCA 781_ PLCNH 786_ YAIND 791_ RLDAI 796_ EDLMV 801_ VPDKI 806_ SEVVE 811_ LLKKL 816_ PDLER 821_ LLSKI 826_ HNVGS 831_ PLKSQ 836_ NHPDS 841_ RAIMY 846_ EETTY 851_ SKKKI 856_ IDFLS 861_ ALEGF 866_ KVMCK 871_ IIGIM 876_ EEVAD 881_ GFKSK 886_ ILKQV 891_ ISLQT 896_ KNPEG 901_ RFPDL 906_ TVELN 911_ RWDTA 916_ FDHEK 921_ ARKTG 926_ LITPK 931_ AGFDS 936_ DYDQA 941_ LADIR 946_ ENEQS 951_ LLEYL 956_ EKQRN 961_ RIGCR 966_ TIVYW 971_ GIGRN 976_ RYQLE 981_ IPENF 986_ TTRNL 991_ PEEYE 996_ LKSTK 1001_ KGCKR 1006_ YWTKT 1011_ IEKKL 1016_ ANLIN 1021_ AEERR 1026_ DVSLK 1031_ DCMRR 1036_ LFYNF 1041_ DKNYK 1046_ DWQSA 1051_ VECIA 1056_ VLDVL 1061_ LCLAN 1066_ YSRGG 1071_ DGPMC 1076_ RPVIL 1081_ LPEDT 1086_ PPFLE 1091_ LKGSR 1096_ HPCIT 1101_ KTFFG 1106_ DDFIP 1111_ NDILI 1116_ GCEEE 1121_ EQENG 1126_ KAYCV 1131_ LVTGP 1136_ NMGGK 1141_ STLMR 1146_ QAGLL 1151_ AVMAQ 1156_ MGCYV 1161_ PAEVC 1166_ RLTPI 1171_ DRVFT 1176_ RLGAS 1181_ DRIMS 1186_ GESTF 1191_ FVELS 1196_ ETASI 1201_ LMHAT 1206_ AHSLV 1211_ LVDEL 1216_ GRGTA 1221_ TFDGT 1226_ AIANA 1231_ VVKEL 1236_ AETIK 1241_ CRTLF 1246_ STHYH 1251_ SLVED 1256_ YSQNV 1261_ AVRLG 1266_ HMACM 1271_ VENEC 1276_ EDPSQ 1281_ ETITF 1286_ LYKFI 1291_ KGACP 1296_ KSYGF 1301_ NAARL 1306_ ANLPE 1311_ EVIQK 1316_ GHRKA 1321_ REFEK 1326_ MNQSL 1331_ RLFRE 1336_ VCLAS 1341_ ERSTV 1346_ DAEAV 1351_HKLLT
1: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction