Zinc finger protein 143 (SPH-binding factor) (Selenocysteine tRNA gene transcription-activating factor) (hStaf)
1_MLLAQ 6_ INRDS 11_ QGMTE 16_ FPGGG 21_ MEAQH 26_ VTLCL 31_ TEAVT 36_ VADGD 41_ NLENM 46_ EGVSL 51_ QAVTL 56_ ADGST 61_ AYIQH 66_ NSKDA 71_ KLIDG 76_ QVIQL 81_ EDGSA 86_ AYVQH 91_ VPIPK 96_ STGDS 101_ LRLED 106_ GQAVQ 111_ LEDGT 116_ TAFIH 121_ HTSKD 126_ SYDQS 131_ ALQAV 136_ QLEDG 141_ TTAYI 146_ HHAVQ 151_ VPQSD 156_ TILAI 161_ QADGT 166_ VAGLH 171_ TGDAT 176_ IDPDT 181_ ISALE 186_ QYAAK 191_ VSIDG 196_ SESVA 201_ GTGMI 206_ GENEQ 211_ EKKMQ 216_ IVLQG 221_ HATRV 226_ TAKSQ 231_ QSGEK 236_ AFRCE 241_ YDGCG 246_ KLYTT 251_ AHHLK 256_ VHERS 261_ HTGDR 266_ PYQCE 271_ HAGCG 276_ KAFAT 281_ GYGLK 286_ SHVRT 291_ HTGEK 296_ PYRCS 301_ EDNCT 306_ KSFKT 311_ SGDLQ 316_ KHIRT 321_ HTGER 326_ PFKCP 331_ FEGCG 336_ RSFTT 341_ SNIRK 346_ VHVRT 351_ HTGER 356_ PYYCT 361_ EPGCG 366_ RAFAS 371_ ATNYK 376_ NHVRI 381_ HTGEK 386_ PYVCT 391_ VPGCD 396_ KRFTE 401_ YSSLY 406_ KHHVV 411_ HTHSK 416_ PYNCN 421_ HCGKT 426_ YKQIS 431_ TLAMH 436_ KRTAH 441_ NDTEP 446_ IEEEQ 451_ EAFFE 456_ PPPGQ 461_ GEDVL 466_ KGSQI 471_ TYVTG 476_ VEGDD 481_ VVSTQ 486_ VATVT 491_ QSGLS 496_ QQVTL 501_ ISQDG 506_ TQHVN 511_ ISQAD 516_ MQAIG 521_ NTITM 526_ VTQDG 531_ TPITV 536_ PAHDA 541_ VISSA 546_ GTHSV 551_ AMVTA 556_ EGTEG 561_ EQVAI 566_ VAQDL 571_ AAFHT 576_ ASSEM 581_ GHQQH 586_ SHHLV 591_ TTETR 596_ PLTLV 601_ ATSNG 606_ TQIAV 611_ QLGEQ 616_ PSLEE 621_ AIRIA 626_ SRIQQ 631_GETPG
1: Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8. In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (PubMed:26416877)