RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9)
1_MGSDK 6_ RVSRT 11_ ERSGR 16_ YGSII 21_ DRDDR 26_ DERES 31_ RSRRR 36_ DSDYK 41_ RSSDD 46_ RRGDR 51_ YDDYR 56_ DYDSP 61_ ERERE 66_ RRNSD 71_ RSEDG 76_ YHSDG 81_ DYGEH 86_ DYRHD 91_ ISDER 96_ ESKTI 101_ MLRGL 106_ PITIT 111_ ESDIR 116_ EMMES 121_ FEGPQ 126_ PADVR 131_ LMKRK 136_ TGVSR 141_ GFAFV 146_ EFYHL 151_ QDATS 156_ WMEAN 161_ QKKLV 166_ IQGKH 171_ IAMHY 176_ SNPRP 181_ KFEDW 186_ LCNKC 191_ CLNNF 196_ RKRLK 201_ CFRCG 206_ ADKFD 211_ SEQEV 216_ PPGTT 221_ ESVQS 226_ VDYYC 231_ DTIIL 236_ RNIAP 241_ HTVVD 246_ SIMTA 251_ LSPYA 256_ SLAVN 261_ NIRLI 266_ KDKQT 271_ QQNRG 276_ FAFVQ 281_ LSSAM 286_ DASQL 291_ LQILQ 296_ SLHPP 301_ LKIDG 306_ KTIGV 311_ DFAKS 316_ ARKDL 321_ VLSDG 326_ NRVSA 331_ FSVAS 336_ TAIAA 341_ AQWSS 346_ TQSQS 351_ GEGGS 356_ VDYSY 361_ LQPGQ 366_ DGYAQ 371_ YAQYS 376_ QDYQQ 381_ FYQQQ 386_ AGGLE 391_ SDASS 396_ ASGTA 401_ VTTTS 406_ AAVVS 411_ QSPQL 416_ YNQTS 421_ NPPGS 426_ PTEEA 431_ QPSTS 436_ TSTQA 441_ PAASP 446_ TGVVP 451_ GTKYA 456_ VPDTS 461_ TYQYD 466_ ESSGY 471_ YYDPT 476_ TGLYY 481_ DPNSQ 486_ YYYNS 491_ LTQQY 496_ LYWDG 501_ EKETY 506_ VPAAE 511_ SSSHQ 516_ QSGLP 521_ PAKEG 526_ KEKKE 531_ KPKSK 536_ TAQQI 541_ AKDME 546_ RWAKS 551_ LNKQK 556_ ENFKN 561_ SFQPV 566_ NSLRE 571_ EERRE 576_ SAAAD 581_ AGFAL 586_ FEKKG 591_ ALAER 596_ QQLIP 601_ ELVRN 606_ GDEEN 611_ PLKRG 616_ LVAAY 621_ SGDSD 626_ NEEEL 631_ VERLE 636_ SEEEK 641_ LADWK 646_ KMACL 651_ LCRRQ 656_ FPNKD 661_ ALVRH 666_ QQLSD 671_ LHKQN 676_ MDIYR 681_ RSRLS 686_ EQELE 691_ ALELR 696_ EREMK 701_ YRDRA 706_ AERRE 711_ KYGIP 716_ EPPEP 721_ KRKKQ 726_ FDAGT 731_ VNYEQ 736_ PTKDG 741_ IDHSN 746_ IGNKM 751_ LQAMG 756_ WREGS 761_ GLGRK 766_ CQGIT 771_ APIEA 776_ QVRLK 781_ GAGLG 786_ AKGSA 791_ YGLSG 796_ ADSYK 801_ DAVRK 806_AMFAR
1: Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis