2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (14.5 kDa translational inhibitor protein) (hp14.5) (p14.5) (Heat-responsive protein 12) (Reactive intermediate imine deaminase A homolog) (Translation inhibitor L-PSP ribonuclease) (UK114 antigen homolog)
1_MSSLI 6_ RRVIS 11_ TAKAP 16_ GAIGP 21_ YSQAV 26_ LVDRT 31_ IYISG 36_ QIGMD 41_ PSSGQ 46_ LVSGG 51_ VAEEA 56_ KQALK 61_ NMGEI 66_ LKAAG 71_ CDFTN 76_ VVKTT 81_ VLLAD 86_ INDFN 91_ TVNEI 96_ YKQYF 101_ KSNFP 106_ ARAAY 111_ QVAAL 116_ PKGSR 121_ IEIEA 126_ VAIQG 131_PLTTA
1: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase
2: Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex (PubMed:30930054, PubMed:8973653). Acts by bridging YTHDF2 and the ribonuclease P/MRP complex (PubMed:30930054). RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage (PubMed:30930054)