Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase)
1_MIASH 6_ LLAYF 11_ FTELN 16_ HDQVQ 21_ KVDQY 26_ LYHMR 31_ LSDET 36_ LLEIS 41_ KRFRK 46_ EMEKG 51_ LGATT 56_ HPTAA 61_ VKMLP 66_ TFVRS 71_ TPDGT 76_ EHGEF 81_ LALDL 86_ GGTNF 91_ RVLWV 96_ KVTDN 101_ GLQKV 106_ EMENQ 111_ IYAIP 116_ EDIMR 121_ GSGTQ 126_ LFDHI 131_ AECLA 136_ NFMDK 141_ LQIKD 146_ KKLPL 151_ GFTFS 156_ FPCHQ 161_ TKLDE 166_ SFLVS 171_ WTKGF 176_ KSSGV 181_ EGRDV 186_ VALIR 191_ KAIQR 196_ RGDFD 201_ IDIVA 206_ VVNDT 211_ VGTMM 216_ TCGYD 221_ DHNCE 226_ IGLIV 231_ GTGSN 236_ ACYME 241_ EMRHI 246_ DMVEG 251_ DEGRM 256_ CINME 261_ WGAFG 266_ DDGSL 271_ NDIRT 276_ EFDQE 281_ IDMGS 286_ LNPGK 291_ QLFEK 296_ MISGM 301_ YMGEL 306_ VRLIL 311_ VKMAK 316_ EELLF 321_ GGKLS 326_ PELLN 331_ TGRFE 336_ TKDIS 341_ DIEGE 346_ KDGIR 351_ KAREV 356_ LMRLG 361_ LDPTQ 366_ EDCVA 371_ THRIC 376_ QIVST 381_ RSASL 386_ CAATL 391_ AAVLQ 396_ RIKEN 401_ KGEER 406_ LRSTI 411_ GVDGS 416_ VYKKH 421_ PHFAK 426_ RLHKT 431_ VRRLV 436_ PGCDV 441_ RFLRS 446_ EDGSG 451_ KGAAM 456_ VTAVA 461_ YRLAD 466_ QHRAR 471_ QKTLE 476_ HLQLS 481_ HDQLL 486_ EVKRR 491_ MKVEM 496_ ERGLS 501_ KETHA 506_ SAPVK 511_ MLPTY 516_ VCATP 521_ DGTEK 526_ GDFLA 531_ LDLGG 536_ TNFRV 541_ LLVRV 546_ RNGKW 551_ GGVEM 556_ HNKIY 561_ AIPQE 566_ VMHGT 571_ GDELF 576_ DHIVQ 581_ CIADF 586_ LEYMG 591_ MKGVS 596_ LPLGF 601_ TFSFP 606_ CQQNS 611_ LDESI 616_ LLKWT 621_ KGFKA 626_ SGCEG 631_ EDVVT 636_ LLKEA 641_ IHRRE 646_ EFDLD 651_ VVAVV 656_ NDTVG 661_ TMMTC 666_ GFEDP 671_ HCEVG 676_ LIVGT 681_ GSNAC 686_ YMEEM 691_ RNVEL 696_ VEGEE 701_ GRMCV 706_ NMEWG 711_ AFGDN 716_ GCLDD 721_ FRTEF 726_ DVAVD 731_ ELSLN 736_ PGKQR 741_ FEKMI 746_ SGMYL 751_ GEIVR 756_ NILID 761_ FTKRG 766_ LLFRG 771_ RISER 776_ LKTRG 781_ IFETK 786_ FLSQI 791_ ESDCL 796_ ALLQV 801_ RAILQ 806_ HLGLE 811_ STCDD 816_ SIIVK 821_ EVCTV 826_ VARRA 831_ AQLCG 836_ AGMAA 841_ VVDRI 846_ RENRG 851_ LDALK 856_ VTVGV 861_ DGTLY 866_ KLHPH 871_ FAKVM 876_ HETVK 881_ DLAPK 886_ CDVSF 891_ LQSED 896_ GSGKG 901_ AALIT 906_ AVACR 911_IREAG
1: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175)