Ephrin-A3 (EFL-2) (EHK1 ligand) (EHK1-L) (EPH-related receptor tyrosine kinase ligand 3) (LERK-3)
1_MAAAP 6_ LLLLL 11_ LLVPV 16_ PLLPL 21_ LAQGP 26_ GGALG 31_ NRHAV 36_ YWNSS 41_ NQHLR 46_ REGYT 51_ VQVNV 56_ NDYLD 61_ IYCPH 66_ YNSSG 71_ VGPGA 76_ GPGPG 81_ GGAEQ 86_ YVLYM 91_ VSRNG 96_ YRTCN 101_ ASQGF 106_ KRWEC 111_ NRPHA 116_ PHSPI 121_ KFSEK 126_ FQRYS 131_ AFSLG 136_ YEFHA 141_ GHEYY 146_ YISTP 151_ THNLH 156_ WKCLR 161_ MKVFV 166_ CCAST 171_ SHSGE 176_ KPVPT 181_ LPQFT 186_ MGPNV 191_ KINVL 196_ EDFEG 201_ ENPQV 206_ PKLEK 211_ SISGT 216_ SPKRE 221_ HLPLA 226_ VGIAF 231_FLMTF
1: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)