Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta)
1_MAAAA 6_ EPGAR 11_ AWLGG 16_ GSPRP 21_ GSPAC 26_ SPVLG 31_ SGGRA 36_ RPGPG 41_ PGPGP 46_ ERAGV 51_ RAPGP 56_ AAAPG 61_ HSFRK 66_ VTLTK 71_ PTFCH 76_ LCSDF 81_ IWGLA 86_ GFLCD 91_ VCNFM 96_ SHEKC 101_ LKHVR 106_ IPCTS 111_ VAPSL 116_ VRVPV 121_ AHCFG 126_ PRGLH 131_ KRKFC 136_ AVCRK 141_ VLEAP 146_ ALHCE 151_ VCELH 156_ LHPDC 161_ VPFAC 166_ SDCRQ 171_ CHQDG 176_ HQDHD 181_ THHHH 186_ WREGN 191_ LPSGA 196_ RCEVC 201_ RKTCG 206_ SSDVL 211_ AGVRC 216_ EWCGV 221_ QAHSL 226_ CSAAL 231_ APECG 236_ FGRLR 241_ SLVLP 246_ PACVR 251_ LLPGG 256_ FSKTQ 261_ SFRIV 266_ EAAEP 271_ GEGGD 276_ GADGS 281_ AAVGP 286_ GRETQ 291_ ATPES 296_ GKQTL 301_ KIFDG 306_ DDAVR 311_ RSQFR 316_ LVTVS 321_ RLAGA 326_ EEVLE 331_ AALRA 336_ HHIPE 341_ DPGHL 346_ ELCRL 351_ PPSSQ 356_ ACDAW 361_ AGGKA 366_ GSAVI 371_ SEEGR 376_ SPGSG 381_ EATPE 386_ AWVIR 391_ ALPRA 396_ QEVLK 401_ IYPGW 406_ LKVGV 411_ AYVSV 416_ RVTPK 421_ STARS 426_ VVLEV 431_ LPLLG 436_ RQAES 441_ PESFQ 446_ LVEVA 451_ MGCRH 456_ VQRTM 461_ LMDEQ 466_ PLLDR 471_ LQDIR 476_ QMSVR 481_ QVSQT 486_ RFYVA 491_ ESRDV 496_ APHVS 501_ LFVGG 506_ LPPGL 511_ SPEEY 516_ SSLLH 521_ EAGAT 526_ KATVV 531_ SVSHI 536_ YSSQG 541_ AVVLD 546_ VACFA 551_ EAERL 556_ YMLLK 561_ DMAVR 566_ GRLLT 571_ ALVLP 576_ DLLHA 581_ KLPPD 586_ SCPLL 591_ VFVNP 596_ KSGGL 601_ KGRDL 606_ LCSFR 611_ KLLNP 616_ HQVFD 621_ LTNGG 626_ PLPGL 631_ HLFSQ 636_ VPCFR 641_ VLVCG 646_ GDGTV 651_ GWVLG 656_ ALEET 661_ RYRLA 666_ CPEPS 671_ VAILP 676_ LGTGN 681_ DLGRV 686_ LRWGA 691_ GYSGE 696_ DPFSV 701_ LLSVD 706_ EADAV 711_ LMDRW 716_ TILLD 721_ AHEAG 726_ SAEND 731_ TADAE 736_ PPKIV 741_ QMSNY 746_ CGIGI 751_ DAELS 756_ LDFHQ 761_ AREEE 766_ PGKFT 771_ SRLHN 776_ KGVYV 781_ RVGLQ 786_ KISHS 791_ RSLHK 796_ QIRLQ 801_ VERQE 806_ VELPS 811_ IEGLI 816_ FINIP 821_ SWGSG 826_ ADLWG 831_ SDSDT 836_ RFEKP 841_ RMDDG 846_ LLEVV 851_ GVTGV 856_ VHMGQ 861_ VQGGL 866_ RSGIR 871_ IAQGS 876_ YFRVT 881_ LLKAT 886_ PVQVD 891_ GEPWV 896_ QAPGH 901_ MIISA 906_ AGPKV 911_ HMLRK 916_ AKQKP 921_ RRAGT 926_ TRDAR 931_ ADAAP 936_APESD
1: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11309392, PubMed:22627129, PubMed:9099683). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701)