Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 2) (NDST-2) (N-heparan sulfate sulfotransferase 2) (N-HSST 2) [Includes: Heparan sulfate N-deacetylase 2 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 2 (EC 2.8.2.-)]
1_MLQLW 6_ KVVRP 11_ ARQLE 16_ LHRLI 21_ LLLIA 26_ FSLGS 31_ MGFLA 36_ YYVST 41_ SPKAK 46_ EPLPL 51_ PLGDC 56_ SSGGA 61_ AGPGP 66_ ARPPV 71_ PPRPP 76_ RPPET 81_ ARTEP 86_ VVLVF 91_ VESAY 96_ SQLGQ 101_ EIVAI 106_ LESSR 111_ FRYST 116_ ELAPG 121_ RGDMP 126_ TLTDN 131_ THGRY 136_ VLVIY 141_ ENLLK 146_ YVNLD 151_ AWSRE 156_ LLDRY 161_ CVEYG 166_ VGIIG 171_ FFRAH 176_ EHSLL 181_ SAQLK 186_ GFPLF 191_ LHSNL 196_ GLRDY 201_ QVNPS 206_ APLLH 211_ LTRPS 216_ RLEPG 221_ PLPGD 226_ DWTIF 231_ QSNHS 236_ TYEPV 241_ LLASL 246_ RPAEP 251_ AVPGP 256_ VLRRA 261_ RLPTV 266_ VQDLG 271_ LHDGI 276_ QRVLF 281_ GHGLS 286_ FWLHK 291_ LIFVD 296_ AVAYL 301_ TGKRL 306_ CLDLD 311_ RYILV 316_ DIDDI 321_ FVGKE 326_ GTRMK 331_ VADVE 336_ ALLTT 341_ QNKLR 346_ TLVPN 351_ FTFNL 356_ GFSGK 361_ FYHTG 366_ TEEED 371_ AGDDM 376_ LLKHR 381_ KEFWW 386_ FPHMW 391_ SHMQP 396_ HLFHN 401_ RSVLA 406_ DQMRL 411_ NKQFA 416_ LEHGI 421_ PTDLG 426_ YAVAP 431_ HHSGV 436_ YPIHT 441_ QLYEA 446_ WKSVW 451_ GIQVT 456_ STEEY 461_ PHLRP 466_ ARYRR 471_ GFIHN 476_ GIMVL 481_ PRQTC 486_ GLFTH 491_ TIFYN 496_ EYPGG 501_ SRELD 506_ RSIRG 511_ GELFL 516_ TVLLN 521_ PISIF 526_ MTHLS 531_ NYGND 536_ RLGLY 541_ TFESL 546_ VRFLQ 551_ CWTRL 556_ RLQTL 561_ PPVPL 566_ AQKYF 571_ ELFPQ 576_ ERSPL 581_ WQNPC 586_ DDKRH 591_ KDIWS 596_ KEKTC 601_ DRLPK 606_ FLIVG 611_ PQKTG 616_ TTAIH 621_ FFLSL 626_ HPAVT 631_ SSFPS 636_ PSTFE 641_ EIQFF 646_ NSPNY 651_ HKGID 656_ WYMDF 661_ FPVPS 666_ NASTD 671_ FLFEK 676_ SATYF 681_ DSEVV 686_ PRRGA 691_ ALLPR 696_ AKIIT 701_ VLTNP 706_ ADRAY 711_ SWYQH 716_ QRAHG 721_ DPVAL 726_ NYTFY 731_ QVISA 736_ SSQTP 741_ LALRS 746_ LQNRC 751_ LVPGY 756_ YSTHL 761_ QRWLT 766_ YYPSG 771_ QLLIV 776_ DGQEL 781_ RTNPA 786_ ASMES 791_ IQKFL 796_ GITPF 801_ LNYTR 806_ TLRFD 811_ DDKGF 816_ WCQGL 821_ EGGKT 826_ RCLGR 831_ SKGRR 836_ YPDMD 841_ TESRL 846_ FLTDF 851_ FRNHN 856_ LELSK 861_ LLSRL 866_ GQPVP 871_ SWLRE 876_ELQHS
1: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413)