Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78)
1_MKPPA 6_ ACAGD 11_ MADAA 16_ SPCSV 21_ VNDLR 26_ WDLSA 31_ QQIEE 36_ RTREL 41_ IEQTK 46_ RVYDQ 51_ VGTQE 56_ FEDVS 61_ YESTL 66_ KALAD 71_ VEVTY 76_ TVQRN 81_ ILDFP 86_ QHVSP 91_ SKDIR 96_ TASTE 101_ ADKKL 106_ SEFDV 111_ EMSMR 116_ EDVYQ 121_ RIVWL 126_ QEKVQ 131_ KDSLR 136_ PEAAR 141_ YLERL 146_ IKLGR 151_ RNGLH 156_ LPRET 161_ QENIK 166_ RIKKK 171_ LSLLC 176_ IDFNK 181_ NLNED 186_ TTFLP 191_ FTLQE 196_ LGGLP 201_ EDFLN 206_ SLEKM 211_ EDGKL 216_ KVTLK 221_ YPHYF 226_ PLLKK 231_ CHVPE 236_ TRRKV 241_ EEAFN 246_ CRCKE 251_ ENCAI 256_ LKELV 261_ TLRAQ 266_ KSRLL 271_ GFHTH 276_ ADYVL 281_ EMNMA 286_ KTSQT 291_ VATFL 296_ DELAQ 301_ KLKPL 306_ GEQER 311_ AVILE 316_ LKRAE 321_ CERRG 326_ LPFDG 331_ RIRAW 336_ DMRYY 341_ MNQVE 346_ ETRYC 351_ VDQNL 356_ LKEYF 361_ PVQVV 366_ THGLL 371_ GIYQE 376_ LLGLA 381_ FHHEE 386_ GASAW 391_ HEDVR 396_ LYTAR 401_ DAASG 406_ EVVGK 411_ FYLDL 416_ YPREG 421_ KYGHA 426_ ACFGL 431_ QPGCL 436_ RQDGS 441_ RQIAI 446_ AAMVA 451_ NFTKP 456_ TADAP 461_ SLLQH 466_ DEVET 471_ YFHEF 476_ GHVMH 481_ QLCSQ 486_ AEFAM 491_ FSGTH 496_ VERDF 501_ VEAPS 506_ QMLEN 511_ WVWEQ 516_ EPLLR 521_ MSRHY 526_ RTGSA 531_ VPREL 536_ LEKLI 541_ ESRQA 546_ NTGLF 551_ NLRQI 556_ VLAKV 561_ DQALH 566_ TQTDA 571_ DPAEE 576_ YARLC 581_ QEILG 586_ VPATP 591_ GTNMP 596_ ATFGH 601_ LAGGY 606_ DAQYY 611_ GYLWS 616_ EVYSM 621_ DMFHT 626_ RFKQE 631_ GVLNS 636_ KVGMD 641_ YRSCI 646_ LRPGG 651_ SEDAS 656_ AMLRR 661_ FLGRD 666_ PKQDA 671_ FLLSK 676_ GLQVG 681_GCEPE
1: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity)