Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357)
1_MDSKY 6_ QCVKL 11_ NDGHF 16_ MPVLG 21_ FGTYA 26_ PAEVP 31_ KSKAL 36_ EAVKL 41_ AIEAG 46_ FHHID 51_ SAHVY 56_ NNEEQ 61_ VGLAI 66_ RSKIA 71_ DGSVK 76_ REDIF 81_ YTSKL 86_ WSNSH 91_ RPELV 96_ RPALE 101_ RSLKN 106_ LQLDY 111_ VDLYL 116_ IHFPV 121_ SVKPG 126_ EEVIP 131_ KDENG 136_ KILFD 141_ TVDLC 146_ ATWEA 151_ MEKCK 156_ DAGLA 161_ KSIGV 166_ SNFNH 171_ RLLEM 176_ ILNKP 181_ GLKYK 186_ PVCNQ 191_ VECHP 196_ YFNQR 201_ KLLDF 206_ CKSKD 211_ IVLVA 216_ YSALG 221_ SHREE 226_ PWVDP 231_ NSPVL 236_ LEDPV 241_ LCALA 246_ KKHKR 251_ TPALI 256_ ALRYQ 261_ LQRGV 266_ VVLAK 271_ SYNEQ 276_ RIRQN 281_ VQVFE 286_ FQLTS 291_ EEMKA 296_ IDGLN 301_ RNVRY 306_ LTLDI 311_ FAGPP 316_NYPFS
1: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:15929998, PubMed:17034817, PubMed:17442338, PubMed:8573067). Also specifically able to produce 17beta-hydroxy-5alpha-androstan-3-one/5alphaDHT (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699)