F-actin-capping protein subunit alpha-1 (CapZ alpha-1)
1_MADFD 6_ DRVSD 11_ EEKVR 16_ IAAKF 21_ ITHAP 26_ PGEFN 31_ EVFND 36_ VRLLL 41_ NNDNL 46_ LREGA 51_ AHAFA 56_ QYNMD 61_ QFTPV 66_ KIEGY 71_ EDQVL 76_ ITEHG 81_ DLGNS 86_ RFLDP 91_ RNKIS 96_ FKFDH 101_ LRKEA 106_ SDPQP 111_ EEADG 116_ GLKSW 121_ RESCD 126_ SALRA 131_ YVKDH 136_ YSNGF 141_ CTVYA 146_ KTIDG 151_ QQTII 156_ ACIES 161_ HQFQP 166_ KNFWN 171_ GRWRS 176_ EWKFT 181_ ITPPT 186_ AQVVG 191_ VLKIQ 196_ VHYYE 201_ DGNVQ 206_ LVSHK 211_ DVQDS 216_ LTVSN 221_ EAQTA 226_ KEFIK 231_ IIENA 236_ ENEYQ 241_ TAISE 246_ NYQTM 251_ SDTTF 256_ KALRR 261_ QLPVT 266_ RTKID 271_ WNKIL 276_ SYKIG 281_KEMQN
1: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)