Pancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1)
1_MNGEE 6_ QYYAA 11_ TQLYK 16_ DPCAF 21_ QRGPA 26_ PEFSA 31_ SPPAC 36_ LYMGR 41_ QPPPP 46_ PPHPF 51_ PGALG 56_ ALEQG 61_ SPPDI 66_ SPYEV 71_ PPLAD 76_ DPAVA 81_ HLHHH 86_ LPAQL 91_ ALPHP 96_ PAGPF 101_ PEGAE 106_ PGVLE 111_ EPNRV 116_ QLPFP 121_ WMKST 126_ KAHAW 131_ KGQWA 136_ GGAYA 141_ AEPEE 146_ NKRTR 151_ TAYTR 156_ AQLLE 161_ LEKEF 166_ LFNKY 171_ ISRPR 176_ RVELA 181_ VMLNL 186_ TERHI 191_ KIWFQ 196_ NRRMK 201_ WKKEE 206_ DKKRG 211_ GGTAV 216_ GGGGV 221_ AEPEQ 226_ DCAVT 231_ SGEEL 236_ LALPP 241_ PPPPG 246_ GAVPP 251_ AAPVA 256_ AREGR 261_ LPPGL 266_ SASPQ 271_ PSSVA 276_PRRPQ
1: Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell