Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase)
1_MNAEP 6_ ERKFG 11_ VVVVG 16_ VGRAG 21_ SVRMR 26_ DLRNP 31_ HPSSA 36_ FLNLI 41_ GFVSR 46_ RELGS 51_ IDGVQ 56_ QISLE 61_ DALSS 66_ QEVEV 71_ AYICS 76_ ESSSH 81_ EDYIR 86_ QFLNA 91_ GKHVL 96_ VEYPM 101_ TLSLA 106_ AAQEL 111_ WELAE 116_ QKGKV 121_ LHEEH 126_ VELLM 131_ EEFAF 136_ LKKEV 141_ VGKDL 146_ LKGSL 151_ LFTAG 156_ PLEEE 161_ RFGFP 166_ AFSGI 171_ SRLTW 176_ LVSLF 181_ GELSL 186_ VSATL 191_ EERKE 196_ DQYMK 201_ MTVCL 206_ ETEKK 211_ SPLSW 216_ IEEKG 221_ PGLKR 226_ NRYLS 231_ FHFKS 236_ GSLEN 241_ VPNVG 246_ VNKNI 251_ FLKDQ 256_ NIFVQ 261_ KLLGQ 266_ FSEKE 271_ LAAEK 276_ KRILH 281_ CLGLA 286_ EEIQK 291_YCCSR
1: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092)