Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
1_MAMAE 6_ GERTE 11_ CAEPP 16_ RDEPP 21_ ADGAL 26_ KRAEE 31_ LKTQA 36_ NDYFK 41_ AKDYE 46_ NAIKF 51_ YSQAI 56_ ELNPS 61_ NAIYY 66_ GNRSL 71_ AYLRT 76_ ECYGY 81_ ALGDA 86_ TRAIE 91_ LDKKY 96_ IKGYY 101_ RRAAS 106_ NMALG 111_ KFRAA 116_ LRDYE 121_ TVVKV 126_ KPHDK 131_ DAKMK 136_ YQECN 141_ KIVKQ 146_ KAFER 151_ AIAGD 156_ EHKRS 161_ VVDSL 166_ DIESM 171_ TIEDE 176_ YSGPK 181_ LEDGK 186_ VTISF 191_ MKELM 196_ QWYKD 201_ QKKLH 206_ RKCAY 211_ QILVQ 216_ VKEVL 221_ SKLST 226_ LVETT 231_ LKETE 236_ KITVC 241_ GDTHG 246_ QFYDL 251_ LNIFE 256_ LNGLP 261_ SETNP 266_ YIFNG 271_ DFVDR 276_ GSFSV 281_ EVILT 286_ LFGFK 291_ LLYPD 296_ HFHLL 301_ RGNHE 306_ TDNMN 311_ QIYGF 316_ EGEVK 321_ AKYTA 326_ QMYEL 331_ FSEVF 336_ EWLPL 341_ AQCIN 346_ GKVLI 351_ MHGGL 356_ FSEDG 361_ VTLDD 366_ IRKIE 371_ RNRQP 376_ PDSGP 381_ MCDLL 386_ WSDPQ 391_ PQNGR 396_ SISKR 401_ GVSCQ 406_ FGPDV 411_ TKAFL 416_ EENNL 421_ DYIIR 426_ SHEVK 431_ AEGYE 436_ VAHGG 441_ RCVTV 446_ FSAPN 451_ YCDQM 456_ GNKAS 461_ YIHLQ 466_ GSDLR 471_ PQFHQ 476_ FTAVP 481_ HPNVK 486_ PMAYA 491_NTLLQ
1: Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:30699359, PubMed:9000529). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:30699359, PubMed:9000529). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (PubMed:14871926, PubMed:16260606, PubMed:21144835). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (PubMed:23102700). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function (By similarity). Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (PubMed:16790549). May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (PubMed:22781750). Dephosphorylates and may play a role in the regulation of TAU/MAPT (PubMed:15546861). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (By similarity). Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (PubMed:30699359)