Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
1_MTVFR 6_ QENVD 11_ DYYDT 16_ GEELG 21_ SGQFA 26_ VVKKC 31_ REKST 36_ GLQYA 41_ AKFIK 46_ KRRTK 51_ SSRRG 56_ VSRED 61_ IEREV 66_ SILKE 71_ IQHPN 76_ VITLH 81_ EVYEN 86_ KTDVI 91_ LILEL 96_ VAGGE 101_ LFDFL 106_ AEKES 111_ LTEEE 116_ ATEFL 121_ KQILN 126_ GVYYL 131_ HSLQI 136_ AHFDL 141_ KPENI 146_ MLLDR 151_ NVPKP 156_ RIKII 161_ DFGLA 166_ HKIDF 171_ GNEFK 176_ NIFGT 181_ PEFVA 186_ PEIVN 191_ YEPLG 196_ LEADM 201_ WSIGV 206_ ITYIL 211_ LSGAS 216_ PFLGD 221_ TKQET 226_ LANVS 231_ AVNYE 236_ FEDEY 241_ FSNTS 246_ ALAKD 251_ FIRRL 256_ LVKDP 261_ KKRMT 266_ IQDSL 271_ QHPWI 276_ KPKDT 281_ QQALS 286_ RKASA 291_ VNMEK 296_ FKKFA 301_ ARKKW 306_ KQSVR 311_ LISLC 316_ QRLSR 321_ SFLSR 326_ SNMSV 331_ ARSDD 336_ TLDEE 341_ DSFVM 346_ KAIIH 351_ AINDD 356_ NVPGL 361_ QHLLG 366_ SLSNY 371_ DVNQP 376_ NKHGT 381_ PPLLI 386_ AAGCG 391_ NIQIL 396_ QLLIK 401_ RGSRI 406_ DVQDK 411_ GGSNA 416_ VYWAA 421_ RHGHV 426_ DTLKF 431_ LSENK 436_ CPLDV 441_ KDKSG 446_ EMALH 451_ VAARY 456_ GHADV 461_ AQLLC 466_ SFGSN 471_ PNIQD 476_ KEEET 481_ PLHCA 486_ AWHGY 491_ YSVAK 496_ ALCEA 501_ GCNVN 506_ IKNRE 511_ GETPL 516_ LTASA 521_ RGYHD 526_ IVECL 531_ AEHGA 536_ DLNAC 541_ DKDGH 546_ IALHL 551_ AVRRC 556_ QMEVI 561_ KTLLS 566_ QGCFV 571_ DYQDR 576_ HGNTP 581_ LHVAC 586_ KDGNM 591_ PIVVA 596_ LCEAN 601_ CNLDI 606_ SNKYG 611_ RTPLH 616_ LAANN 621_ GILDV 626_ VRYLC 631_ LMGAS 636_ VEALT 641_ TDGKT 646_ AEDLA 651_ RSEQH 656_ EHVAG 661_ LLARL 666_ RKDTH 671_ RGLFI 676_ QQLRP 681_ TQNLQ 686_ PRIKL 691_ KLFGH 696_ SGSGK 701_ TTLVE 706_ SLKCG 711_ LLRSF 716_ FRRRR 721_ PRLSS 726_ TNSSR 731_ FPPSP 736_ LASKP 741_ TVSVS 746_ INNLY 751_ PGCEN 756_ VSVRS 761_ RSMMF 766_ EPGLT 771_ KGMLE 776_ VFVAP 781_ THHPH 786_ CSADD 791_ QSTKA 796_ IDIQN 801_ AYLNG 806_ VGDFS 811_ VWEFS 816_ GNPVY 821_ FCCYD 826_ YFAAN 831_ DPTSI 836_ HVVVF 841_ SLEEP 846_ YEIQL 851_ NQVIF 856_ WLSFL 861_ KSLVP 866_ VEEPI 871_ AFGGK 876_ LKNPL 881_ QVVLV 886_ ATHAD 891_ IMNVP 896_ RPAGG 901_ EFGYD 906_ KDTSL 911_ LKEIR 916_ NRFGN 921_ DLHIS 926_ NKLFV 931_ LDAGA 936_ SGSKD 941_ MKVLR 946_ NHLQE 951_ IRSQI 956_ VSVCP 961_ PMTHL 966_ CEKII 971_ STLPS 976_ WRKLN 981_ GPNQL 986_ MSLQQ 991_ FVYDV 996_ QDQLN 1001_ PLASE 1006_ EDLRR 1011_ IAQQL 1016_ HSTGE 1021_ INIMQ 1026_ SETVQ 1031_ DVLLL 1036_ DPRWL 1041_ CTNVL 1046_ GKLLS 1051_ VETPR 1056_ ALHHY 1061_ RGRYT 1066_ VEDIQ 1071_ RLVPD 1076_ SDVEE 1081_ LLQIL 1086_ DAMDI 1091_ CARDL 1096_ SSGTM 1101_ VDVPA 1106_ LIKTD 1111_ NLHRS 1116_ WADEE 1121_ DEVMV 1126_ YGGVR 1131_ IVPVE 1136_ HLTPF 1141_ PCGIF 1146_ HKVQV 1151_ NLCRW 1156_ IHQQS 1161_ TEGDA 1166_ DIRLW 1171_ VNGCK 1176_ LANRG 1181_ AELLV 1186_ LLVNH 1191_ GQGIE 1196_ VQVRG 1201_ LETEK 1206_ IKCCL 1211_ LLDSV 1216_ CSTIE 1221_ NVMAT 1226_ TLPGL 1231_ LTVKH 1236_ YLSPQ 1241_ QLREH 1246_ HEPVM 1251_ IYQPR 1256_ DFFRA 1261_ QTLKE 1266_ TSLTN 1271_ TMGGY 1276_ KESFS 1281_ SIMCF 1286_ GCHDV 1291_ YSQAS 1296_ LGMDI 1301_ HASDL 1306_ NLLTR 1311_ RKLSR 1316_ LLDPP 1321_ DPLGK 1326_ DWCLL 1331_ AMNLG 1336_ LPDLV 1341_ AKYNT 1346_ SNGAP 1351_ KDFLP 1356_ SPLHA 1361_ LLREW 1366_ TTYPE 1371_ STVGT 1376_ LMSKL 1381_ RELGR 1386_ RDAAD 1391_ FLLKA 1396_ SSVFK 1401_ INLDG 1406_ NGQEA 1411_ YASSC 1416_ NSGTS 1421_YNSIS
1: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition
2: Isoform 2 cannot induce apoptosis but can induce membrane blebbing