Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (POR1)
1_MTDGI 6_ LGKAA 11_ TMEIP 16_ IHGNG 21_ EARQL 26_ PEDDG 31_ LEQDL 36_ QQVMV 41_ SGPNL 46_ NETSI 51_ VSGGY 56_ GGSGD 61_ GLIPT 66_ GSGRH 71_ PSHST 76_ TPSGP 81_ GDEVA 86_ RGIAG 91_ EKFDI 96_ VKKWG 101_ INTYK 106_ CTKQL 111_ LSERF 116_ GRGSR 121_ TVDLE 126_ LELQI 131_ ELLRE 136_ TKRKY 141_ ESVLQ 146_ LGRAL 151_ TAHLY 156_ SLLQT 161_ QHALG 166_ DAFAD 171_ LSQKS 176_ PELQE 181_ EFGYN 186_ AETQK 191_ LLCKN 196_ GETLL 201_ GAVNF 206_ FVSSI 211_ NTLVT 216_ KTMED 221_ TLMTV 226_ KQYEA 231_ ARLEY 236_ DAYRT 241_ DLEEL 246_ SLGPR 251_ DAGTR 256_ GRLES 261_ AQATF 266_ QAHRD 271_ KYEKL 276_ RGDVA 281_ IKLKF 286_ LEENK 291_ IKVMH 296_ KQLLL 301_ FHNAV 306_ SAYFA 311_ GNQKQ 316_ LEQTL 321_ QQFNI 326_ KLRPP 331_ GAEKP 336_SWLEE
1: Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network (PubMed:26507660). May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site (PubMed:30917996, PubMed:31204568). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658)