Arfaptin-1 (ADP-ribosylation factor-interacting protein 1)
1_MAQES 6_ PKNSA 11_ AEIPV 16_ TSNGE 21_ VDDSR 26_ EHSFN 31_ RDLKH 36_ SLPSG 41_ LGLSE 46_ TQITS 51_ HGFDN 56_ TKEGV 61_ IEAGA 66_ FQGSP 71_ APPLP 76_ SVMSP 81_ SRVAA 86_ SRLAQ 91_ QGSDL 96_ IVPAG 101_ GQRTQ 106_ TKSGP 111_ VILAD 116_ EIKNP 121_ AMEKL 126_ ELVRK 131_ WSLNT 136_ YKCTR 141_ QIISE 146_ KLGRG 151_ SRTVD 156_ LELEA 161_ QIDIL 166_ RDNKK 171_ KYENI 176_ LKLAQ 181_ TLSTQ 186_ LFQMV 191_ HTQRQ 196_ LGDAF 201_ ADLSL 206_ KSLEL 211_ HEEFG 216_ YNADT 221_ QKLLA 226_ KNGET 231_ LLGAI 236_ NFFIA 241_ SVNTL 246_ VNKTI 251_ EDTLM 256_ TVKQY 261_ ESARI 266_ EYDAY 271_ RTDLE 276_ ELNLG 281_ PRDAN 286_ TLPKI 291_ EQSQH 296_ LFQAH 301_ KEKYD 306_ KMRND 311_ VSVKL 316_ KFLEE 321_ NKVKV 326_ LHNQL 331_ VLFHN 336_ AIAAY 341_ FAGNQ 346_ KQLEQ 351_ TLKQF 356_ HIKLK 361_ TPGVD 366_APSWL
1: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988)