Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
1_MTATL 6_ AAAAD 11_ IATMV 16_ SGSSG 21_ LAAAR 26_ LLSRS 31_ FLLPQ 36_ NGIRH 41_ CSYTA 46_ SRQHL 51_ YVDKN 56_ TKIIC 61_ QGFTG 66_ KQGTF 71_ HSQQA 76_ LEYGT 81_ KLVGG 86_ TTPGK 91_ GGQTH 96_ LGLPV 101_ FNTVK 106_ EAKEQ 111_ TGATA 116_ SVIYV 121_ PPPFA 126_ AAAIN 131_ EAIEA 136_ EIPLV 141_ VCITE 146_ GIPQQ 151_ DMVRV 156_ KHKLL 161_ RQEKT 166_ RLIGP 171_ NCPGV 176_ INPGE 181_ CKIGI 186_ MPGHI 191_ HKKGR 196_ IGIVS 201_ RSGTL 206_ TYEAV 211_ HQTTQ 216_ VGLGQ 221_ SLCVG 226_ IGGDP 231_ FNGTD 236_ FIDCL 241_ EIFLN 246_ DSATE 251_ GIILI 256_ GEIGG 261_ NAEEN 266_ AAEFL 271_ KQHNS 276_ GPNSK 281_ PVVSF 286_ IAGLT 291_ APPGR 296_ RMGHA 301_ GAIIA 306_ GGKGG 311_ AKEKI 316_ SALQS 321_ AGVVV 326_ SMSPA 331_ QLGTT 336_ IYKEF 341_EKRKM
1: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits