Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase)
1_MASEK 6_ PLAAV 11_ TCTAP 16_ VNIAV 21_ IKYWG 26_ KRDEE 31_ LVLPI 36_ NSSLS 41_ VTLHQ 46_ DQLKT 51_ TTTAV 56_ ISKDF 61_ TEDRI 66_ WLNGR 71_ EEDVG 76_ QPRLQ 81_ ACLRE 86_ IRCLA 91_ RKRRN 96_ SRDGD 101_ PLPSS 106_ LSCKV 111_ HVASV 116_ NNFPT 121_ AAGLA 126_ SSAAG 131_ YACLA 136_ YTLAR 141_ VYGVE 146_ SDLSE 151_ VARRG 156_ SGSAC 161_ RSLYG 166_ GFVEW 171_ QMGEQ 176_ ADGKD 181_ SIARQ 186_ VAPES 191_ HWPEL 196_ RVLIL 201_ VVSAE 206_ KKLTG 211_ STVGM 216_ RASVE 221_ TSPLL 226_ RFRAE 231_ SVVPA 236_ RMAEM 241_ ARCIR 246_ ERDFP 251_ SFAQL 256_ TMKDS 261_ NQFHA 266_ TCLDT 271_ FPPIS 276_ YLNAI 281_ SWRII 286_ HLVHR 291_ FNAHH 296_ GDTKV 301_ AYTFD 306_ AGPNA 311_ VIFTL 316_ DDTVA 321_ EFVAA 326_ VWHGF 331_ PPGSN 336_ GDTFL 341_ KGLQV 346_ RPAPL 351_ SAELQ 356_ AALAM 361_ EPTPG 366_ GVKYI 371_ IVTQV 376_ GPGPQ 381_ ILDDP 386_ CAHLL 391_GPDGL
1: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis