Coatomer subunit beta (Beta-coat protein) (Beta-COP)
1_MTAAE 6_ NVCYT 11_ LINVP 16_ MDSEP 21_ PSEIS 26_ LKNDL 31_ EKGDV 36_ KSKTE 41_ ALKKV 46_ IIMIL 51_ NGEKL 56_ PGLLM 61_ TIIRF 66_ VLPLQ 71_ DHTIK 76_ KLLLV 81_ FWEIV 86_ PKTTP 91_ DGRLL 96_ HEMIL 101_ VCDAY 106_ RKDLQ 111_ HPNEF 116_ IRGST 121_ LRFLC 126_ KLKEA 131_ ELLEP 136_ LMPAI 141_ RACLE 146_ HRHSY 151_ VRRNA 156_ VLAIY 161_ TIYRN 166_ FEHLI 171_ PDAPE 176_ LIHDF 181_ LVNEK 186_ DASCK 191_ RNAFM 196_ MLIHA 201_ DQDRA 206_ LDYLS 211_ TCIDQ 216_ VQTFG 221_ DILQL 226_ VIVEL 231_ IYKVC 236_ HANPS 241_ ERARF 246_ IRCIY 251_ NLLQS 256_ SSPAV 261_ KYEAA 266_ GTLVT 271_ LSSAP 276_ TAIKA 281_ AAQCY 286_ IDLII 291_ KESDN 296_ NVKLI 301_ VLDRL 306_ IELKE 311_ HPAHE 316_ RVLQD 321_ LVMDI 326_ LRVLS 331_ TPDLE 336_ VRKKT 341_ LQLAL 346_ DLVSS 351_ RNVEE 356_ LVIVL 361_ KKEVI 366_ KTNNV 371_ SEHED 376_ TDKYR 381_ QLLVR 386_ TLHSC 391_ SVRFP 396_ DMAAN 401_ VIPVL 406_ MEFLS 411_ DNNEA 416_ AAADV 421_ LEFVR 426_ EAIQR 431_ FDNLR 436_ MLIVE 441_ KMLEV 446_ FHAIK 451_ SVKIY 456_ RGALW 461_ ILGEY 466_ CSTKE 471_ DIQSV 476_ MTEIR 481_ RSLGE 486_ IPIVE 491_ SEIKK 496_ EAGEL 501_ KPEEE 506_ ITVGP 511_ VQKLV 516_ TEMGT 521_ YATQS 526_ ALSSS 531_ RPTKK 536_ EEDRP 541_ PLRGF 546_ LLDGD 551_ FFVAA 556_ SLATT 561_ LTKIA 566_ LRYVA 571_ LVQEK 576_ KKQNS 581_ FVAEA 586_ MLLMA 591_ TILHL 596_ GKSSL 601_ PKKPI 606_ TDDDV 611_ DRISL 616_ CLKVL 621_ SECSP 626_ LMNDI 631_ FNKEC 636_ RQSLS 641_ HMLSA 646_ KLEEE 651_ KLSQK 656_ KESEK 661_ RNVTV 666_ QPDDP 671_ ISFMQ 676_ LTAKN 681_ EMNCK 686_ EDQFQ 691_ LSLLA 696_ AMGNT 701_ QRKEA 706_ ADPLA 711_ SKLNK 716_ VTQLT 721_ GFSDP 726_ VYAEA 731_ YVHVN 736_ QYDIV 741_ LDVLV 746_ VNQTS 751_ DTLQN 756_ CTLEL 761_ ATLGD 766_ LKLVE 771_ KPSPL 776_ TLAPH 781_ DFANI 786_ KANVK 791_ VASTE 796_ NGIIF 801_ GNIVY 806_ DVSGA 811_ ASDRN 816_ CVVLS 821_ DIHID 826_ IMDYI 831_ QPATC 836_ TDAEF 841_ RQMWA 846_ EFEWE 851_ NKVTV 856_ NTNMV 861_ DLNDY 866_ LQHIL 871_ KSTNM 876_ KCLTP 881_ EKALS 886_ GYCGF 891_ MAANL 896_ YARSI 901_ FGEDA 906_ LANVS 911_ IEKPI 916_ HQGPD 921_ AAVTG 926_ HIRIR 931_ AKSQG 936_ MALSL 941_ GDKIN 946_LSQKK
1: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments