Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)]
1_MGAGP 6_ SLLLA 11_ ALLLL 16_ LSGDG 21_ AVRCD 26_ TPANC 31_ TYLDL 36_ LGTWV 41_ FQVGS 46_ SGSQR 51_ DVNCS 56_ VMGPQ 61_ EKKVV 66_ VYLQK 71_ LDTAY 76_ DDLGN 81_ SGHFT 86_ IIYNQ 91_ GFEIV 96_ LNDYK 101_ WFAFF 106_ KYKEE 111_ GSKVT 116_ TYCNE 121_ TMTGW 126_ VHDVL 131_ GRNWA 136_ CFTGK 141_ KVGTA 146_ SENVY 151_ VNIAH 156_ LKNSQ 161_ EKYSN 166_ RLYKY 171_ DHNFV 176_ KAINA 181_ IQKSW 186_ TATTY 191_ MEYET 196_ LTLGD 201_ MIRRS 206_ GGHSR 211_ KIPRP 216_ KPAPL 221_ TAEIQ 226_ QKILH 231_ LPTSW 236_ DWRNV 241_ HGINF 246_ VSPVR 251_ NQASC 256_ GSCYS 261_ FASMG 266_ MLEAR 271_ IRILT 276_ NNSQT 281_ PILSP 286_ QEVVS 291_ CSQYA 296_ QGCEG 301_ GFPYL 306_ IAGKY 311_ AQDFG 316_ LVEEA 321_ CFPYT 326_ GTDSP 331_ CKMKE 336_ DCFRY 341_ YSSEY 346_ HYVGG 351_ FYGGC 356_ NEALM 361_ KLELV 366_ HHGPM 371_ AVAFE 376_ VYDDF 381_ LHYKK 386_ GIYHH 391_ TGLRD 396_ PFNPF 401_ ELTNH 406_ AVLLV 411_ GYGTD 416_ SASGM 421_ DYWIV 426_ KNSWG 431_ TGWGE 436_ NGYFR 441_ IRRGT 446_ DECAI 451_ ESIAV 456_AATPI
1: Thiol protease (PubMed:1586157). Has dipeptidylpeptidase activity (PubMed:1586157). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:1586157). Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1586157). Can act as both an exopeptidase and endopeptidase (PubMed:1586157). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (PubMed:8428921)