LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1)
1_MRLTL 6_ LCCTW 11_ REERM 16_ GEEGS 21_ ELPVC 26_ ASCGQ 31_ RIYDG 36_ QYLQA 41_ LNADW 46_ HADCF 51_ RCCDC 56_ SASLS 61_ HQYYE 66_ KDGQL 71_ FCKKD 76_ YWARY 81_ GESCH 86_ GCSEQ 91_ ITKGL 96_ VMVAG 101_ ELKYH 106_ PECFI 111_ CLTCG 116_ TFIGD 121_ GDTYT 126_ LVEHS 131_ KLYCG 136_ HCYYQ 141_ TVVTP 146_ VIEQI 151_ LPDSP 156_ GSHLP 161_ HTVTL 166_ VSIPA 171_ SSHGK 176_ RGLSV 181_ SIDPP 186_ HGPPG 191_ CGTEH 196_ SHTVR 201_ VQGVD 206_ PGCMS 211_ PDVKN 216_ SIHVG 221_ DRILE 226_ INGTP 231_ IRNVP 236_ LDEID 241_ LLIQE 246_ TSRLL 251_ QLTLE 256_ HDPHD 261_ TLGHG 266_ LGPET 271_ SPLSS 276_ PAYTP 281_ SGEAG 286_ SSARQ 291_ KPVLR 296_ SCSID 301_ RSPGA 306_ GSLGS 311_ PASQR 316_ KDLGR 321_ SESLR 326_ VVCRP 331_ HRIFR 336_ PSDLI 341_ HGEVL 346_ GKGCF 351_ GQAIK 356_ VTHRE 361_ TGEVM 366_ VMKEL 371_ IRFDE 376_ ETQRT 381_ FLKEV 386_ KVMRC 391_ LEHPN 396_ VLKFI 401_ GVLYK 406_ DKRLN 411_ FITEY 416_ IKGGT 421_ LRGII 426_ KSMDS 431_ QYPWS 436_ QRVSF 441_ AKDIA 446_ SGMAY 451_ LHSMN 456_ IIHRD 461_ LNSHN 466_ CLVRE 471_ NKNVV 476_ VADFG 481_ LARLM 486_ VDEKT 491_ QPEGL 496_ RSLKK 501_ PDRKK 506_ RYTVV 511_ GNPYW 516_ MAPEM 521_ INGRS 526_ YDEKV 531_ DVFSF 536_ GIVLC 541_ EIIGR 546_ VNADP 551_ DYLPR 556_ TMDFG 561_ LNVRG 566_ FLDRY 571_ CPPNC 576_ PPSFF 581_ PITVR 586_ CCDLD 591_ PEKRP 596_ SFVKL 601_ EHWLE 606_ TLRMH 611_ LAGHL 616_ PLGPQ 621_ LEQLD 626_ RGFWE 631_ TYRRG 636_ ESGLP 641_AHPEV
1: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908)
2: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1)