LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1)
1_MSALA 6_ GEDVW 11_ RCPGC 16_ GDHIA 21_ PSQIW 26_ YRTVN 31_ ETWHG 36_ SCFRC 41_ SECQD 46_ SLTNW 51_ YYEKD 56_ GKLYC 61_ PKDYW 66_ GKFGE 71_ FCHGC 76_ SLLMT 81_ GPFMV 86_ AGEFK 91_ YHPEC 96_ FACMS 101_ CKVII 106_ EDGDA 111_ YALVQ 116_ HATLY 121_ CGKCH 126_ NEVVL 131_ APMFE 136_ RLSTE 141_ SVQEQ 146_ LPYSV 151_ TLISM 156_ PATTE 161_ GRRGF 166_ SVSVE 171_ SACSN 176_ YATTV 181_ QVKEV 186_ NRMHI 191_ SPNNR 196_ NAIHP 201_ GDRIL 206_ EINGT 211_ PVRTL 216_ RVEEV 221_ EDAIS 226_ QTSQT 231_ LQLLI 236_ EHDPV 241_ SQRLD 246_ QLRLE 251_ ARLAP 256_ HMQNA 261_ GHPHA 266_ LSTLD 271_ TKENL 276_ EGTLR 281_ RRSLR 286_ RSNSI 291_ SKSPG 296_ PSSPK 301_ EPLLF 306_ SRDIS 311_ RSESL 316_ RCSSS 321_ YSQQI 326_ FRPCD 331_ LIHGE 336_ VLGKG 341_ FFGQA 346_ IKVTH 351_ KATGK 356_ VMVMK 361_ ELIRC 366_ DEETQ 371_ KTFLT 376_ EVKVM 381_ RSLDH 386_ PNVLK 391_ FIGVL 396_ YKDKK 401_ LNLLT 406_ EYIEG 411_ GTLKD 416_ FLRSM 421_ DPFPW 426_ QQKVR 431_ FAKGI 436_ ASGMA 441_ YLHSM 446_ CIIHR 451_ DLNSH 456_ NCLIK 461_ LDKTV 466_ VVADF 471_ GLSRL 476_ IVEER 481_ KRAPM 486_ EKATT 491_ KKRTL 496_ RKNDR 501_ KKRYT 506_ VVGNP 511_ YWMAP 516_ EMLNG 521_ KSYDE 526_ TVDIF 531_ SFGIV 536_ LCEII 541_ GQVYA 546_ DPDCL 551_ PRTLD 556_ FGLNV 561_ KLFWE 566_ KFVPT 571_ DCPPA 576_ FFPLA 581_ AICCR 586_ LEPES 591_ RPAFS 596_ KLEDS 601_ FEALS 606_ LYLGE 611_ LGIPL 616_ PAELE 621_ ELDHT 626_ VSMQY 631_GLTRD
1: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865)