Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]
1_MSPGA 6_ SRGPR 11_ GSQAP 16_ LIAPL 21_ CCAAA 26_ ALGML 31_ LWSPA 36_ CQAFN 41_ LDVEK 46_ LTVYS 51_ GPKGS 56_ YFGYA 61_ VDFHI 66_ PDART 71_ ASVLV 76_ GAPKA 81_ NTSQP 86_ DIVEG 91_ GAVYY 96_ CPWPA 101_ EGSAQ 106_ CRQIP 111_ FDTTN 116_ NRKIR 121_ VNGTK 126_ EPIEF 131_ KSNQW 136_ FGATV 141_ KAHKG 146_ KVVAC 151_ APLYH 156_ WRTLK 161_ PTPEK 166_ DPVGT 171_ CYVAI 176_ QNFSA 181_ YAEFS 186_ PCRNS 191_ NADPE 196_ GQGYC 201_ QAGFS 206_ LDFYK 211_ NGDLI 216_ VGGPG 221_ SFYWQ 226_ GQVIT 231_ ASVAD 236_ IIANY 241_ SFKDI 246_ LRKLA 251_ GEKQT 256_ EVAPA 261_ SYDDS 266_ YLGYS 271_ VAAGE 276_ FTGDS 281_ QQELV 286_ AGIPR 291_ GAQNF 296_ GYVSI 301_ INSTD 306_ MTFIQ 311_ NFTGE 316_ QMASY 321_ FGYTV 326_ VVSDV 331_ NSDGL 336_ DDVLV 341_ GAPLF 346_ MEREF 351_ ESNPR 356_ EVGQI 361_ YLYLQ 366_ VSSLL 371_ FRDPQ 376_ ILTGT 381_ ETFGR 386_ FGSAM 391_ AHLGD 396_ LNQDG 401_ YNDIA 406_ IGVPF 411_ AGKDQ 416_ RGKVL 421_ IYNGN 426_ KDGLN 431_ TKPSQ 436_ VLQGV 441_ WASHA 446_ VPSGF 451_ GFTLR 456_ GDSDI 461_ DKNDY 466_ PDLIV 471_ GAFGT 476_ GKVAV 481_ YRARP 486_ VVTVD 491_ AQLLL 496_ HPMII 501_ NLENK 506_ TCQVP 511_ DSMTS 516_ AACFS 521_ LRVCA 526_ SVTGQ 531_ SIANT 536_ IVLMA 541_ EVQLD 546_ SLKQK 551_ GAIKR 556_ TLFLD 561_ NHQAH 566_ RVFPL 571_ VIKRQ 576_ KSHQC 581_ QDFIV 586_ YLRDE 591_ TEFRD 596_ KLSPI 601_ NISLN 606_ YSLDE 611_ STFKE 616_ GLEVK 621_ PILNY 626_ YRENI 631_ VSEQA 636_ HILVD 641_ CGEDN 646_ LCVPD 651_ LKLSA 656_ RPDKH 661_ QVIIG 666_ DENHL 671_ MLIIN 676_ ARNEG 681_ EGAYE 686_ AELFV 691_ MIPEE 696_ ADYVG 701_ IERNN 706_ KGFRP 711_ LSCEY 716_ KMENV 721_ TRMVV 726_ CDLGN 731_ PMVSG 736_ TNYSL 741_ GLRFA 746_ VPRLE 751_ KTNMS 756_ INFDL 761_ QIRSS 766_ NKDNP 771_ DSNFV 776_ SLQIN 781_ ITAVA 786_ QVEIR 791_ GVSHP 796_ PQIVL 801_ PIHNW 806_ EPEEE 811_ PHKEE 816_ EVGPL 821_ VEHIY 826_ ELHNI 831_ GPSTI 836_ SDTIL 841_ EVGWP 846_ FSARD 851_ EFLLY 856_ IFHIQ 861_ TLGPL 866_ QCQPN 871_ PNINP 876_ QDIKP 881_ AASPE 886_ DTPEL 891_ SAFLR 896_ NSTIP 901_ HLVRK 906_ RDVHV 911_ VEFHR 916_ QSPAK 921_ ILNCT 926_ NIECL 931_ QISCA 936_ VGRLE 941_ GGESA 946_ VLKVR 951_ SRLWA 956_ HTFLQ 961_ RKNDP 966_ YALAS 971_ LVSFE 976_ VKKMP 981_ YTDQP 986_ AKLPE 991_ GSIVI 996_ KTSVI 1001_ WATPN 1006_ VSFSI 1011_ PLWVI 1016_ ILAIL 1021_ LGLLV 1026_ LAILT 1031_ LALWK 1036_ CGFFD 1041_ RARPP 1046_ QEDMT 1051_ DREQL 1056_TNDKT
1: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons