Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
1_MSSPP 6_ PARSG 11_ FYRQE 16_ VTKTA 21_ WEVRA 26_ VYRDL 31_ QPVGS 36_ GAYGA 41_ VCSAV 46_ DGRTG 51_ AKVAI 56_ KKLYR 61_ PFQSE 66_ LFAKR 71_ AYREL 76_ RLLKH 81_ MRHEN 86_ VIGLL 91_ DVFTP 96_ DETLD 101_ DFTDF 106_ YLVMP 111_ FMGTD 116_ LGKLM 121_ KHEKL 126_ GEDRI 131_ QFLVY 136_ QMLKG 141_ LRYIH 146_ AAGII 151_ HRDLK 156_ PGNLA 161_ VNEDC 166_ ELKIL 171_ DFGLA 176_ RQADS 181_ EMTGY 186_ VVTRW 191_ YRAPE 196_ VILNW 201_ MRYTQ 206_ TVDIW 211_ SVGCI 216_ MAEMI 221_ TGKTL 226_ FKGSD 231_ HLDQL 236_ KEIMK 241_ VTGTP 246_ PAEFV 251_ QRLQS 256_ DEAKN 261_ YMKGL 266_ PELEK 271_ KDFAS 276_ ILTNA 281_ SPLAV 286_ NLLEK 291_ MLVLD 296_ AEQRV 301_ TAGEA 306_ LAHPY 311_ FESLH 316_ DTEDE 321_ PQVQK 326_ YDDSF 331_ DDVDR 336_ TLDEW 341_ KRVTY 346_ KEVLS 351_ FKPPR 356_ QLGAR 361_VSKET
1: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration