Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
1_MSLHF 6_ LYYCS 11_ EPTLD 16_ VKIAF 21_ CQGFD 26_ KQVDV 31_ SYIAK 36_ HYNMS 41_ KSKVD 46_ NQFYS 51_ VEVGD 56_ STFTV 61_ LKRYQ 66_ NLKPI 71_ GSGAQ 76_ GIVCA 81_ AYDAV 86_ LDRNV 91_ AIKKL 96_ SRPFQ 101_ NQTHA 106_ KRAYR 111_ ELVLM 116_ KCVNH 121_ KNIIS 126_ LLNVF 131_ TPQKT 136_ LEEFQ 141_ DVYLV 146_ MELMD 151_ ANLCQ 156_ VIQME 161_ LDHER 166_ MSYLL 171_ YQMLC 176_ GIKHL 181_ HSAGI 186_ IHRDL 191_ KPSNI 196_ VVKSD 201_ CTLKI 206_ LDFGL 211_ ARTAG 216_ TSFMM 221_ TPYVV 226_ TRYYR 231_ APEVI 236_ LGMGY 241_ KENVD 246_ IWSVG 251_ CIMGE 256_ MVRHK 261_ ILFPG 266_ RDYID 271_ QWNKV 276_ IEQLG 281_ TPCPE 286_ FMKKL 291_ QPTVR 296_ NYVEN 301_ RPKYA 306_ GLTFP 311_ KLFPD 316_ SLFPA 321_ DSEHN 326_ KLKAS 331_ QARDL 336_ LSKML 341_ VIDPA 346_ KRISV 351_ DDALQ 356_ HPYIN 361_ VWYDP 366_ AEVEA 371_ PPPQI 376_ YDKQL 381_ DEREH 386_ TIEEW 391_ KELIY 396_ KEVMN 401_ SEEKT 406_ KNGVV 411_ KGQPS 416_ PSGAA 421_ VNSSE 426_ SLPPS 431_ SSVND 436_ ISSMS 441_ TDQTL 446_ ASDTD 451_ SSLEA 456_SAGPL
1: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Also participates in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296)