E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)
1_MDNFA 6_ EGDFT 11_ VADYA 16_ LLEDC 21_ PHVDD 26_ CVFAA 31_ EFMSN 36_ DYVRV 41_ TQLYC 46_ DGVGV 51_ QYKDY 56_ IQSER 61_ NLEFD 66_ ICSIW 71_ CSKPI 76_ SVLQD 81_ YCDAI 86_ KINIF 91_ WPLLF 96_ QHQNS 101_ SVISR 106_ LHPCV 111_ DANNS 116_ RASEI 121_ NLKKL 126_ QHLEL 131_ MEDIV 136_ DLAKK 141_ VANDS 146_ FLIGG 151_ LLRIG 156_ CKIEN 161_ KILAM 166_ EEALN 171_ WIKYA 176_ GDVTI 181_ LTKLG 186_ SIDNC 191_ WPMLS 196_ IFFTE 201_ YKYHI 206_ TKIVM 211_ EDCNL 216_ LEELK 221_ TQSCM 226_ DCIEE 231_ GELMK 236_ MKGNE 241_ EFSKE 246_ RFDIA 251_ IIYYT 256_ RAIEY 261_ RPENY 266_ LLYGN 271_ RALCF 276_ LRTGQ 281_ FRNAL 286_ GDGKR 291_ ATILK 296_ NTWPK 301_ GHYRY 306_ CDALS 311_ MLGEY 316_ DWALQ 321_ ANIKA 326_ QKLCK 331_ NDPEG 336_ IKDLI 341_ QQHVK 346_ LQKQI 351_ EDLQG 356_ RTANK 361_ DPIKA 366_ FYENR 371_ AYTPR 376_ SLSAP 381_ IFTTS 386_ LNFVE 391_ KERDF 396_ RKINH 401_ EMANG 406_ GNQNL 411_ KVADE 416_ ALKVD 421_ DCDCH 426_ PEFSP 431_ PSSQP 436_ PKHKG 441_ KQKSR 446_ NNESE 451_ KFSSS 456_ SPLTL 461_ PADLK 466_ NILEK 471_ QFSKS 476_ SRAAH 481_ QDFAN 486_ IMKML 491_ RSLIQ 496_ DGYMA 501_ LLEQR 506_ CRSAA 511_ QAFTE 516_ LLNGL 521_ DPQKI 526_ KQLNL 531_ AMINY 536_ VLVVY 541_ GLAIS 546_ LLGIG 551_ QPEEL 556_ SEAEN 561_ QFKRI 566_ IEHYP 571_ SEGLD 576_ CLAYC 581_ GIGKV 586_ YLKKN 591_ RFLEA 596_ LNHFE 601_ KARTL 606_ IYRLP 611_ GVLTW 616_ PTSNV 621_ IIEES 626_ QPQKI 631_ KMLLE 636_ KFVEE 641_ CKFPP 646_ VPDAI 651_ CCYQK 656_ CHGYS 661_ KIQIY 666_ ITDPD 671_ FKGFI 676_ RISCC 681_ QYCKI 686_ EFHMN 691_ CWKKL 696_ KTTTF 701_ NDKID 706_ KDFLQ 711_ GICLT 716_ PDCEG 721_ VISKI 726_ IIFSS 731_ GGEVK 736_ CEFEH 741_ KVIKE 746_ KVPPR 751_ PILKQ 756_ KCSSL 761_ EKLRL 766_ KEDKK 771_ LKRKI 776_ QKKEA 781_ KKLAQ 786_ ERMEE 791_ DLRES 796_ NPPKN 801_ EEQKE 806_ TVDNV 811_ QRCQF 816_ LDDRI 821_ LQCIK 826_ QYADK 831_ IKSGI 836_ QNTAM 841_ LLKEL 846_ LSWKV 851_ LSTED 856_ YTTCF 861_ SSRNF 866_ LNEAV 871_ DYVIR 876_ HLIQE 881_ NNRVK 886_ TRIFL 891_ HVLSE 896_ LKEVE 901_ PKLAA 906_ WIQKL 911_ NSFGL 916_ DATGT 921_ FFSRY 926_ GASLK 931_ LLDFS 936_ IMTFL 941_ WNEKY 946_ GHKLD 951_ SIEGK 956_ QLDYF 961_ SEPAS 966_ LKEAR 971_ CLIWL 976_ LEEHR 981_ DKFPA 986_ LHSAL 991_ DEFFD 996_ IMDSR 1001_ CTVLR 1006_ KQDSG 1011_ EAPFS 1016_ STKVK 1021_ NKSKK 1026_ KKPKD 1031_ SKPML 1036_ VGSGT 1041_ TSVTS 1046_ NNEII 1051_ TSSED 1056_ HSNRN 1061_ SDSAG 1066_ PFAVP 1071_ DHLRQ 1076_ DVEEF 1081_ EALYD 1086_ QHSNE 1091_ YVVRN 1096_ KKLWD 1101_ MNPKQ 1106_ KCSTL 1111_ YDYFS 1116_ QFLEE 1121_ HGPLD 1126_ MSNKM 1131_ FSAEY 1136_ EFFPE 1141_ ETRQI 1146_ LEKAG 1151_ GLKPF 1156_ LLGCP 1161_ RFVVI 1166_ DNCIA 1171_ LKKVA 1176_ SRLKK 1181_ KRKKK 1186_ NIKTK 1191_ VEEIS 1196_ KAGEY 1201_ VRVKL 1206_ QLNPA 1211_ AREFK 1216_ PDVKS 1221_ KPVSD 1226_ SSSAP 1231_ AFENV 1236_ KPKPV 1241_ SANSP 1246_ KPACE 1251_ DVKAK 1256_ PVSDN 1261_ SSRQV 1266_ SEDGQ 1271_ PKGVS 1276_ SNSPK 1281_ PGSED 1286_ ANYKR 1291_ VSCNS 1296_ PKPVL 1301_ EDVKP 1306_ TYWAQ 1311_ SHLVT 1316_ GYCTY 1321_ LPFQR 1326_ FDITQ 1331_ TPPAY 1336_ INVLP 1341_ GLPQY 1346_ TSIYT 1351_ PLASL 1356_ SPEYQ 1361_ LPRSV 1366_ PVVPS 1371_ FVAND 1376_ RADKN 1381_ AAAYF 1386_ EGHHL 1391_ NAENV 1396_ AGHQI 1401_ ASETQ 1406_ ILEGS 1411_ LGISV 1416_ KSHCS 1421_ TGDAH 1426_ TVLSE 1431_ SNRND 1436_ EHCGN 1441_ SNNKC 1446_ EVIPE 1451_ STSAV 1456_ TNIPH 1461_ VQMVA 1466_ IQVSW 1471_ NIIHQ 1476_ EVNTE 1481_ PYNPF 1486_ EERQG 1491_ EISRI 1496_ EKEHQ 1501_ VLQDQ 1506_ LQEVY 1511_ ENYEQ 1516_ IKLKG 1521_ LEETR 1526_ DLEEK 1531_ LKRHL 1536_ EENKI 1541_ SKTEL 1546_ DWFLQ 1551_ DLERE 1556_ IKKWQ 1561_ QEKKE 1566_ IQERL 1571_ KSLKK 1576_ KIKKV 1581_ SNASE 1586_ MYTQK 1591_ NDGKE 1596_ KEHEL 1601_ HLDQS 1606_ LEISN 1611_ TLTNE 1616_ KMKIE 1621_ EYIKK 1626_ GKEDY 1631_ EESHQ 1636_ RAVAA 1641_ EVSVL 1646_ ENWKE 1651_ SEVYK 1656_ LQIME 1661_ SQAEA 1666_ FLKKL 1671_ GLISR 1676_ DPAAY 1681_ PDMES 1686_ DIRSW 1691_ ELFLS 1696_ NVTKE 1701_ IEKAK 1706_ SQFEE 1711_ QIKAI 1716_ KNGSR 1721_ LSELS 1726_ KVQIS 1731_ ELSFP 1736_ ACNTV 1741_ HPELL 1746_ PESSG 1751_ DDGQG 1756_ LVTSA 1761_ SDVTG 1766_ NHAAL 1771_ HRDPS 1776_ VFSAG 1781_ DSPGE 1786_ APSAL 1791_ LPGPP 1796_ PGQPE 1801_ ATQLT 1806_ GPKRA 1811_ GQAAL 1816_ SERSP 1821_ VADRK 1826_ QPVPP 1831_ GRAAR 1836_ SSQSP 1841_ KKPFN 1846_ SIIEH 1851_ LSVVF 1856_ PCYNS 1861_ TELAG 1866_ FIKKV 1871_ RSKNK 1876_ NSLSG 1881_ LSIDE 1886_ IVQRV 1891_ TEHIL 1896_ DEQKK 1901_ KKPNP 1906_ GKDKR 1911_ TYEPS 1916_ SATPV 1921_ TRSSQ 1926_ GSPSV 1931_ VVAPS 1936_ PKTKG 1941_ QKAED 1946_ VPVRI 1951_ ALGAS 1956_ SCEIC 1961_ HEVFK 1966_ SKNVR 1971_ VLKCG 1976_ HKYHK 1981_ GCFKQ 1986_ WLKGQ 1991_ SACPA 1996_ CQGRD 2001_ LLTEE 2006_ SPSGR 2011_ GWPSQ 2016_NQELP
1: E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323)