Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1)
1_MPPAV 6_ GGPVG 11_ YTPPD 16_ GGWGW 21_ AVVIG 26_ AFISI 31_ GFSYA 36_ FPKSI 41_ TVFFK 46_ EIEGI 51_ FHATT 56_ SEVSW 61_ ISSIM 66_ LAVMY 71_ GGGPI 76_ SSILV 81_ NKYGS 86_ RIVMI 91_ VGGCL 96_ SGCGL 101_ IAASF 106_ CNTVQ 111_ QLYVC 116_ IGVIG 121_ GLGLA 126_ FNLNP 131_ ALTMI 136_ GKYFY 141_ KRRPL 146_ ANGLA 151_ MAGSP 156_ VFLCT 161_ LAPLN 166_ QVFFG 171_ IFGWR 176_ GSFLI 181_ LGGLL 186_ LNCCV 191_ AGALM 196_ RPIGP 201_ KPTKA 206_ GKDKS 211_ KASLE 216_ KAGKS 221_ GVKKD 226_ LHDAN 231_ TDLIG 236_ RHPKQ 241_ EKRSV 246_ FQTIN 251_ QFLDL 256_ TLFTH 261_ RGFLL 266_ YLSGN 271_ VIMFF 276_ GLFAP 281_ LVFLS 286_ SYGKS 291_ QHYSS 296_ EKSAF 301_ LLSIL 306_ AFVDM 311_ VARPS 316_ MGLVA 321_ NTKPI 326_ RPRIQ 331_ YFFAA 336_ SVVAN 341_ GVCHM 346_ LAPLS 351_ TTYVG 356_ FCVYA 361_ GFFGF 366_ AFGWL 371_ SSVLF 376_ ETLMD 381_ LVGPQ 386_ RFSSA 391_ VGLVT 396_ IVECC 401_ PVLLG 406_ PPLLG 411_ RLNDM 416_ YGDYK 421_ YTYWA 426_ CGVVL 431_ IISGI 436_ YLFIG 441_ MGINY 446_ RLLAK 451_ EQKAN 456_ EQKKE 461_ SKEEE 466_ TSIDV 471_ AGKPN 476_ EVTKA 481_ AESPD 486_ QKDTD 491_GGPKE
1: Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811). Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023)