IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28)
1_MLGSG 6_ FKAER 11_ LRVNL 16_ RLVIN 21_ RLKLL 26_ EKKKT 31_ ELAQK 36_ ARKEI 41_ ADYLA 46_ AGKDE 51_ RARIR 56_ VEHII 61_ REDYL 66_ VEAME 71_ ILELY 76_ CDLLL 81_ ARFGL 86_ IQSMK 91_ ELDSG 96_ LAESV 101_ STLIW 106_ AAPRL 111_ QSEVA 116_ ELKIV 121_ ADQLC 126_ AKYSK 131_ EYGKL 136_ CRTNQ 141_ IGTVN 146_ DRLMH 151_ KLSVE 156_ APPKI 161_ LVERY 166_ LIEIA 171_ KNYNV 176_ PYEPD 181_ SVVMA 186_ EAPPG 191_ VETDL 196_ IDVGF 201_ TDDVK 206_ KGGPG 211_ RGGSG 216_ GFTAP 221_ VGGPD 226_ GTVPM 231_ PMPMP 236_ MPSAN 241_ TPFSY 246_ PLPKG 251_ PSDFN 256_ GLPMG 261_ TYQAF 266_ PNIHP 271_ PQIPA 276_ TPPSY 281_ ESVDD 286_ INADK 291_ NISSA 296_ QIVGP 301_ GPKPE 306_ ASAKL 311_ PSRPA 316_ DNYDN 321_ FVLPE 326_ LPSVP 331_ DTLPT 336_ ASAGA 341_ STSAS 346_ EDIDF 351_ DDLSR 356_RFEEL
1: ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888)