Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14)
1_MPKSK 6_ ELVSS 11_ SSSGS 16_ DSDSE 21_ VDKKL 26_ KRKKQ 31_ VAPEK 36_ PVKKQ 41_ KTGET 46_ SRALS 51_ SSKQS 56_ SSSRD 61_ DNMFQ 66_ IGKMR 71_ YVSVR 76_ DFKGK 81_ VLIDI 86_ REYWM 91_ DPEGE 96_ MKPGR 101_ KGISL 106_ NPEQW 111_ SQLKE 116_ QISDI 121_DDAVR
1: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA)