Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)
1_MSFLK 6_ SFPPP 11_ GPAEG 16_ LLRQQ 21_ PDTEA 26_ VLNGK 31_ GLGTG 36_ TLYIA 41_ ESRLS 46_ WLDGS 51_ GLGFS 56_ LEYPT 61_ ISLHA 66_ LSRDR 71_ SDCLG 76_ EHLYV 81_ MVNAK 86_ FEEES 91_ KEPVA 96_ DEEEE 101_ DSDDD 106_ VEPIT 111_ EFRFV 116_ PSDKS 121_ ALEAM 126_ FTAMC 131_ ECQAL 136_ HPDPE 141_ DEDSD 146_ DYDGE 151_ EYDVE 156_ AHEQG 161_ QGDIP 166_ TFYTY 171_ EEGLS 176_ HLTAE 181_ GQATL 186_ ERLEG 191_ MLSQS 196_ VSSQY 201_ NMAGV 206_ RTEDS 211_ IRDYE 216_ DGMEV 221_ DTTPT 226_ VAGQF 231_EDADV
1: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:10330151, PubMed:18984161). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:10330151). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:10330151, PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:10330151, PubMed:18984161)