Bloom syndrome protein (EC 3.6.4.12) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)
1_MAAVP 6_ QNNLQ 11_ EQLER 16_ HSART 21_ LNNKL 26_ SLSKP 31_ KFSGF 36_ TFKKK 41_ TSSDN 46_ NVSVT 51_ NVSVA 56_ KTPVL 61_ RNKDV 66_ NVTED 71_ FSFSE 76_ PLPNT 81_ TNQQR 86_ VKDFF 91_ KNAPA 96_ GQETQ 101_ RGGSK 106_ SLLPD 111_ FLQTP 116_ KEVVC 121_ TTQNT 126_ PTVKK 131_ SRDTA 136_ LKKLE 141_ FSSSP 146_ DSLST 151_ INDWD 156_ DMDDF 161_ DTSET 166_ SKSFV 171_ TPPQS 176_ HFVRV 181_ STAQK 186_ SKKGK 191_ RNFFK 196_ AQLYT 201_ TNTVK 206_ TDLPP 211_ PSSES 216_ EQIDL 221_ TEEQK 226_ DDSEW 231_ LSSDV 236_ ICIDD 241_ GPIAE 246_ VHINE 251_ DAQES 256_ DSLKT 261_ HLEDE 266_ RDNSE 271_ KKKNL 276_ EEAEL 281_ HSTEK 286_ VPCIE 291_ FDDDD 296_ YDTDF 301_ VPPSP 306_ EEIIS 311_ ASSSS 316_ SKCLS 321_ TLKDL 326_ DTSDR 331_ KEDVL 336_ STSKD 341_ LLSKP 346_ EKMSM 351_ QELNP 356_ ETSTD 361_ CDARQ 366_ ISLQQ 371_ QLIHV 376_ MEHIC 381_ KLIDT 386_ IPDDK 391_ LKLLD 396_ CGNEL 401_ LQQRN 406_ IRRKL 411_ LTEVD 416_ FNKSD 421_ ASLLG 426_ SLWRY 431_ RPDSL 436_ DGPME 441_ GDSCP 446_ TGNSM 451_ KELNF 456_ SHLPS 461_ NSVSP 466_ GDCLL 471_ TTTLG 476_ KTGFS 481_ ATRKN 486_ LFERP 491_ LFNTH 496_ LQKSF 501_ VSSNW 506_ AETPR 511_ LGKKN 516_ ESSYF 521_ PGNVL 526_ TSTAV 531_ KDQNK 536_ HTASI 541_ NDLER 546_ ETQPS 551_ YDIDN 556_ FDIDD 561_ FDDDD 566_ DWEDI 571_ MHNLA 576_ ASKSS 581_ TAAYQ 586_ PIKEG 591_ RPIKS 596_ VSERL 601_ SSAKT 606_ DCLPV 611_ SSTAQ 616_ NINFS 621_ ESIQN 626_ YTDKS 631_ AQNLA 636_ SRNLK 641_ HERFQ 646_ SLSFP 651_ HTKEM 656_ MKIFH 661_ KKFGL 666_ HNFRT 671_ NQLEA 676_ INAAL 681_ LGEDC 686_ FILMP 691_ TGGGK 696_ SLCYQ 701_ LPACV 706_ SPGVT 711_ VVISP 716_ LRSLI 721_ VDQVQ 726_ KLTSL 731_ DIPAT 736_ YLTGD 741_ KTDSE 746_ ATNIY 751_ LQLSK 756_ KDPII 761_ KLLYV 766_ TPEKI 771_ CASNR 776_ LISTL 781_ ENLYE 786_ RKLLA 791_ RFVID 796_ EAHCV 801_ SQWGH 806_ DFRQD 811_ YKRMN 816_ MLRQK 821_ FPSVP 826_ VMALT 831_ ATANP 836_ RVQKD 841_ ILTQL 846_ KILRP 851_ QVFSM 856_ SFNRH 861_ NLKYY 866_ VLPKK 871_ PKKVA 876_ FDCLE 881_ WIRKH 886_ HPYDS 891_ GIIYC 896_ LSRRE 901_ CDTMA 906_ DTLQR 911_ DGLAA 916_ LAYHA 921_ GLSDS 926_ ARDEV 931_ QQKWI 936_ NQDGC 941_ QVICA 946_ TIAFG 951_ MGIDK 956_ PDVRF 961_ VIHAS 966_ LPKSV 971_ EGYYQ 976_ ESGRA 981_ GRDGE 986_ ISHCL 991_ LFYTY 996_ HDVTR 1001_ LKRLI 1006_ MMEKD 1011_ GNHHT 1016_ RETHF 1021_ NNLYS 1026_ MVHYC 1031_ ENITE 1036_ CRRIQ 1041_ LLAYF 1046_ GENGF 1051_ NPDFC 1056_ KKHPD 1061_ VSCDN 1066_ CCKTK 1071_ DYKTR 1076_ DVTDD 1081_ VKSIV 1086_ RFVQE 1091_ HSSSQ 1096_ GMRNI 1101_ KHVGP 1106_ SGRFT 1111_ MNMLV 1116_ DIFLG 1121_ SKSAK 1126_ IQSGI 1131_ FGKGS 1136_ AYSRH 1141_ NAERL 1146_ FKKLI 1151_ LDKIL 1156_ DEDLY 1161_ INAND 1166_ QAIAY 1171_ VMLGN 1176_ KAQTV 1181_ LNGNL 1186_ KVDFM 1191_ ETENS 1196_ SSVKK 1201_ QKALV 1206_ AKVSQ 1211_ REEMV 1216_ KKCLG 1221_ ELTEV 1226_ CKSLG 1231_ KVFGV 1236_ HYFNI 1241_ FNTVT 1246_ LKKLA 1251_ ESLSS 1256_ DPEVL 1261_ LQIDG 1266_ VTEDK 1271_ LEKYG 1276_ AEVIS 1281_ VLQKY 1286_ SEWTS 1291_ PAEDS 1296_ SPGIS 1301_ LSSSR 1306_ GPGRS 1311_ AAEEL 1316_ DEEIP 1321_ VSSHY 1326_ FASKT 1331_ RNERK 1336_ RKKMP 1341_ ASQRS 1346_ KRRKT 1351_ ASSGS 1356_ KAKGG 1361_ SATCR 1366_ KISSK 1371_ TKSSS 1376_ IIGSS 1381_ SASHT 1386_ SQATS 1391_ GANSK 1396_ LGIMA 1401_ PPKPI 1406_ NRPFL 1411_KPSYA
1: ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity)
2: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration