Protein HIRA (TUP1-like enhancer of split protein 1)
1_MKLLK 6_ PTWVN 11_ HNGKP 16_ IFSVD 21_ IHPDG 26_ TKFAT 31_ GGQGQ 36_ DSGKV 41_ VIWNM 46_ SPVLQ 51_ EDDEK 56_ DENIP 61_ KMLCQ 66_ MDNHL 71_ ACVNC 76_ VRWSN 81_ SGMYL 86_ ASGGD 91_ DKLIM 96_ VWKRA 101_ TYIGP 106_ STVFG 111_ SSGKL 116_ ANVEQ 121_ WRCVS 126_ ILRNH 131_ SGDVM 136_ DVAWS 141_ PHDAW 146_ LASCS 151_ VDNTV 156_ VIWNA 161_ VKFPE 166_ ILATL 171_ RGHSG 176_ LVKGL 181_ TWDPV 186_ GKYIA 191_ SQADD 196_ RSLKV 201_ WRTLD 206_ WQLET 211_ SITKP 216_ FDECG 221_ GTTHV 226_ LRLSW 231_ SPDGH 236_ YLVSA 241_ HAMNN 246_ SGPTA 251_ QIIER 256_ EGWKT 261_ NMDFV 266_ GHRKA 271_ VTVVK 276_ FNPKI 281_ FKKKQ 286_ KNGSS 291_ AKPSC 296_ PYCCC 301_ AVGSK 306_ DRSLS 311_ VWLTC 316_ LKRPL 321_ VVIHE 326_ LFDKS 331_ IMDIS 336_ WTLNG 341_ LGILV 346_ CSMDG 351_ SVAFL 356_ DFSQD 361_ ELGDP 366_ LSEEE 371_ KSRIH 376_ QSTYG 381_ KSLAI 386_ MTEAQ 391_ LSTAV 396_ IENPE 401_ MLKYQ 406_ RRQQQ 411_ QQLDQ 416_ KSAAT 421_ REMGS 426_ ATSVA 431_ GVVNG 436_ ESLED 441_ IRKNL 446_ LKKQV 451_ ETRTA 456_ DGRRR 461_ ITPLC 466_ IAQLD 471_ TGDFS 476_ TAFFN 481_ SIPLS 486_ GSLAG 491_ TMLSS 496_ HSSPQ 501_ LLPLD 506_ SSTPN 511_ SFGAS 516_ KPCTE 521_ PVVAA 526_ SARPA 531_ GDSVN 536_ KDSMN 541_ ATSTP 546_ AALSP 551_ SVLTT 556_ PSKIE 561_ PMKAF 566_ DSRFT 571_ ERSKA 576_ TPGAP 581_ ALTSM 586_ TPTAV 591_ ERLKE 596_ QNLVK 601_ ELRPR 606_ DLLES 611_ SSDSD 616_ EKVPL 621_ AKASS 626_ LSKRK 631_ LELEV 636_ ETVEK 641_ KKKGR 646_ PRKDS 651_ RLMPV 656_ SLSVQ 661_ SPAAL 666_ TAEKE 671_ AMCLS 676_ APALA 681_ LKLPI 686_ PSPQR 691_ AFTLQ 696_ VSSDP 701_ SMYIE 706_ VENEV 711_ TVVGG 716_ VKLSR 721_ LKCNR 726_ EGKEW 731_ ETVLT 736_ SRILT 741_ AAGSC 746_ DVVCV 751_ ACEKR 756_ MLSVF 761_ STCGR 766_ RLLSP 771_ ILLPS 776_ PISTL 781_ HCTGS 786_ YVMAL 791_ TAAAT 796_ LSVWD 801_ VHRQV 806_ VVVKE 811_ ESLHS 816_ ILAGS 821_ DMTVS 826_ QILLT 831_ QHGIP 836_ VMNLS 841_ DGKAY 846_ CFNPS 851_ LSTWN 856_ LVSDK 861_ QDSLA 866_ QCADF 871_ RSSLP 876_ SQDAM 881_ LCSGP 886_ LAIIQ 891_ GRTSN 896_ SGRQA 901_ ARLFS 906_ VPHVV 911_ QQETT 916_ LAYLE 921_ NQVAA 926_ ALTLQ 931_ SSHEY 936_ RHWLL 941_ VYARY 946_ LVNEG 951_ FEYRL 956_ REICK 961_ DLLGP 966_ VHYST 971_ GSQWE 976_ STVVG 981_ LRKRE 986_ LLKEL 991_ LPVIG 996_ QNLRF 1001_ QRLFT 1006_ ECQEQ 1011_LDILR
1: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit