Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1)
1_MAEDV 6_ SSAAP 11_ SPRGC 16_ ADGRD 21_ ADPTE 26_ EQMAE 31_ TERND 36_ EEQFE 41_ CQELL 46_ ECQVQ 51_ VGAPE 56_ EEEEE 61_ EEDAG 66_ LVAEA 71_ EAVAA 76_ GWMLD 81_ FLCLS 86_ LCRAF 91_ RDGRS 96_ EDFRR 101_ TRNSA 106_ EAIIH 111_ GLSSL 116_ TACQL 121_ RTIYI 126_ CQFLT 131_ RIAAG 136_ KTLDA 141_ QFEND 146_ ERITP 151_ LESAL 156_ MIWGS 161_ IEKEH 166_ DKLHE 171_ EIQNL 176_ IKIQA 181_ IAVCM 186_ ENGNF 191_ KEAEE 196_ VFERI 201_ FGDPN 206_ SHMPF 211_ KSKLL 216_ MIISQ 221_ KDTFH 226_ SFFQH 231_ FSYNH 236_ MMEKI 241_ KSYVN 246_ YVLSE 251_ KSSTF 256_ LMKAA 261_ AKVVE 266_ SKRTR 271_ TITSQ 276_ DKPSG 281_ NDVEM 286_ ETEAN 291_ LDTRK 296_ SVSDK 301_ QSAVT 306_ ESSEG 311_ TVSLL 316_ RSHKN 321_ LFLSK 326_ LQHGT 331_ QQQDL 336_ NKKER 341_ RVGTP 346_ QSTKK 351_ KKESR 356_ RATES 361_ RIPVS 366_ KSQPV 371_ TPEKH 376_ RARKR 381_ QAWLW 386_ EEDKN 391_ LRSGV 396_ RKYGE 401_ GNWSK 406_ ILLHY 411_ KFNNR 416_ TSVML 421_ KDRWR 426_ TMKKL 431_KLISS
1: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways