Pancreatic lipase-related protein 2 (PL-RP2) (Cytotoxic T lymphocyte lipase) (Galactolipase) (EC 3.1.1.26) (Triacylglycerol lipase) (EC 3.1.1.3)
1_MLPPW 6_ TLGLL 11_ LLATV 16_ RGKEV 21_ CYGQL 26_ GCFSD 31_ EKPWA 36_ GTLQR 41_ PVKLL 46_ PWSPE 51_ DIDTR 56_ FLLYT 61_ NENPN 66_ NFQLI 71_ TGTEP 76_ DTIEA 81_ SNFQL 86_ DRKTR 91_ FIIHG 96_ FLDKA 101_ EDSWP 106_ SDMCK 111_ KMFEV 116_ EKVNC 121_ ICVDW 126_ RHGSR 131_ AMYTQ 136_ AVQNI 141_ RVVGA 146_ ETAFL 151_ IQALS 156_ TQLGY 161_ SLEDV 166_ HVIGH 171_ SLGAH 176_ TAAEA 181_ GRRLG 186_ GRVGR 191_ ITGLD 196_ PAGPC 201_ FQDEP 206_ EEVRL 211_ DPSDA 216_ VFVDV 221_ IHTDS 226_ SPIVP 231_ SLGFG 236_ MSQKV 241_ GHLDF 246_ FPNGG 251_ KEMPG 256_ CKKNV 261_ LSTIT 266_ DIDGI 271_ WEGIG 276_ GFVSC 281_ NHLRS 286_ FEYYS 291_ SSVLN 296_ PDGFL 301_ GYPCA 306_ SYDEF 311_ QESKC 316_ FPCPA 321_ EGCPK 326_ MGHYA 331_ DQFKG 336_ KTSAV 341_ EQTFF 346_ LNTGE 351_ SGNFT 356_ SWRYK 361_ ISVTL 366_ SGKEK 371_ VNGYI 376_ RIALY 381_ GSNEN 386_ SKQYE 391_ IFKGS 396_ LKPDA 401_ SHTCA 406_ IDVDF 411_ NVGKI 416_ QKVKF 421_ LWNKR 426_ GINLS 431_ EPKLG 436_ ASQIT 441_ VQSGE 446_ DGTEY 451_ NFCSS 456_ DTVEE 461_NVLQS
1: Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:15287741, PubMed:17401110, PubMed:18702514, PubMed:19451396, PubMed:20083229, PubMed:21865348, PubMed:26494624). In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (PubMed:19824014, PubMed:21652702, PubMed:23732775). Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:15287741, PubMed:17401110, PubMed:18702514, PubMed:21652702, PubMed:21865348). Can completely deacylate triacylglycerols (PubMed:21865348). When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (PubMed:15287741, PubMed:17401110, PubMed:18702514, PubMed:20083229, PubMed:26494624). Hydrolyzes medium- and long-chain fatty acyls in galactolipids (PubMed:18702514, PubMed:20083229). May act together with LIPF to hydrolyze partially digested triglycerides (PubMed:23732775). Hydrolyzes long-chain monoglycerides with high efficiency (PubMed:17401110, PubMed:21652702, PubMed:23732775). In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity (PubMed:17401110, PubMed:18702514). In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity)