Ornithine decarboxylase antizyme 1 (AZ1) (ODC-Az)
1_MVKSS 6_ LQRIL 11_ NSHCF 16_ AREKE 21_ GDKPS 26_ ATIHA 31_ SRTMP 36_ LLSLH 41_ SRGGS 46_ SSESS 51_ RVSLH 56_ CCSNP 61_ GPGPR 66_ WCSDA 71_ PHPPL 76_ KIPGG 81_ RGNSQ 86_ RDHNL 91_ SANLF 96_ YSDDR 101_ LNVTE 106_ ELTSN 111_ DKTRI 116_ LNVQS 121_ RLTDA 126_ KRINW 131_ RTVLS 136_ GGSLY 141_ IEIPG 146_ GALPE 151_ GSKDS 156_ FAVLL 161_ EFAEE 166_ QLRAD 171_ HVFIC 176_ FHKNR 181_ EDRAA 186_ LLRTF 191_ SFLGF 196_ EIVRP 201_ GHPLV 206_ PKRPD 211_ ACFMA 216_ YTFER 221_ESSGE
1: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147)