Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed]
1_MGDAP 6_ SPEEK 11_ LHLIT 16_ RNLQE 21_ VLGEE 26_ KLKEI 31_ LKERE 36_ LKIYW 41_ GTATT 46_ GKPHV 51_ AYFVP 56_ MSKIA 61_ DFLKA 66_ GCEVT 71_ ILFAD 76_ LHAYL 81_ DNMKA 86_ PWELL 91_ ELRVS 96_ YYENV 101_ IKAML 106_ ESIGV 111_ PLEKL 116_ KFIKG 121_ TDYQL 126_ SKEYT 131_ LDVYR 136_ LSSVV 141_ TQHDS 146_ KKAGA 151_ EVVKQ 156_ VEHPL 161_ LSGLL 166_ YPGLQ 171_ ALDEE 176_ YLKVD 181_ AQFGG 186_ IDQRK 191_ IFTFA 196_ EKYLP 201_ ALGYS 206_ KRVHL 211_ MNPMV 216_ PGLTG 221_ SKMSS 226_ SEEES 231_ KIDLL 236_ DRKED 241_ VKKKL 246_ KKAFC 251_ EPGNV 256_ ENNGV 261_ LSFIK 266_ HVLFP 271_ LKSEF 276_ VILRD 281_ EKWGG 286_ NKTYT 291_ AYVDL 296_ EKDFA 301_ AEVVH 306_ PGDLK 311_ NSVEV 316_ ALNKL 321_ LDPIR 326_ EKFNT 331_ PALKK 336_ LASAA 341_ YPDPS 346_ KQKPM 351_ AKGPA 356_ KNSEP 361_ EEVIP 366_ SRLDI 371_ RVGKI 376_ ITVEK 381_ HPDAD 386_ SLYVE 391_ KIDVG 396_ EAEPR 401_ TVVSG 406_ LVQFV 411_ PKEEL 416_ QDRLV 421_ VVLCN 426_ LKPQK 431_ MRGVE 436_ SQGML 441_ LCASI 446_ EGINR 451_ QVEPL 456_ DPPAG 461_ SAPGE 466_ HVFVK 471_ GYEKG 476_ QPDEE 481_ LKPKK 486_ KVFEK 491_ LQADF 496_ KISEE 501_ CIAQW 506_ KQTNF 511_ MTKLG 516_ SISCK 521_SLKGG
1: Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) (PubMed:25533949). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity (PubMed:25533949). Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:25533949)