UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)
1_MAVTI 6_ TLKTL 11_ QQQTF 16_ KIRME 21_ PDETV 26_ KVLKE 31_ KIEAE 36_ KGRDA 41_ FPVAG 46_ QKLIY 51_ AGKIL 56_ SDDVP 61_ IRDYR 66_ IDEKN 71_ FVVVM 76_ VTKTK 81_ AGQGT 86_ SAPPE 91_ ASPTA 96_ APESS 101_ TSFPP 106_ APTSG 111_ MSHPP 116_ PAARE 121_ DKSPS 126_ EESAP 131_ TTSPE 136_ SVSGS 141_ VPSSG 146_ SSGRE 151_ EDAAS 156_ TLVTG 161_ SEYET 166_ MLTEI 171_ MSMGY 176_ ERERV 181_ VAALR 186_ ASYNN 191_ PHRAV 196_ EYLLT 201_ GIPGS 206_ PEPEH 211_ GSVQE 216_ SQVSE 221_ QPATE 226_ AAGEN 231_ PLEFL 236_ RDQPQ 241_ FQNMR 246_ QVIQQ 251_ NPALL 256_ PALLQ 261_ QLGQE 266_ NPQLL 271_ QQISR 276_ HQEQF 281_ IQMLN 286_ EPPGE 291_ LADIS 296_ DVEGE 301_ VGAIG 306_ EEAPQ 311_ MNYIQ 316_ VTPQE 321_ KEAIE 326_ RLKAL 331_ GFPES 336_ LVIQA 341_ YFACE 346_ KNENL 351_ AANFL 356_LSQNF
1: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome
2: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC
3: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome