Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)
1_MRGSG 6_ PRGAG 11_ RRRPP 16_ SGGGD 21_ TPITP 26_ ASLAG 31_ CYSAP 36_ RRAPL 41_ WTCLL 46_ LCAAL 51_ RTLLA 56_ SPSNE 61_ VNLLD 66_ SRTVM 71_ GDLGW 76_ IAFPK 81_ NGWEE 86_ IGEVD 91_ ENYAP 96_ IHTYQ 101_ VCKVM 106_ EQNQN 111_ NWLLT 116_ SWISN 121_ EGASR 126_ IFIEL 131_ KFTLR 136_ DCNSL 141_ PGGLG 146_ TCKET 151_ FNMYY 156_ FESDD 161_ QNGRN 166_ IKENQ 171_ YIKID 176_ TIAAD 181_ ESFTE 186_ LDLGD 191_ RVMKL 196_ NTEVR 201_ DVGPL 206_ SKKGF 211_ YLAFQ 216_ DVGAC 221_ IALVS 226_ VRVYY 231_ KKCPS 236_ VVRHL 241_ AVFPD 246_ TITGA 251_ DSSQL 256_ LEVSG 261_ SCVNH 266_ SVTDE 271_ PPKMH 276_ CSAEG 281_ EWLVP 286_ IGKCM 291_ CKAGY 296_ EEKNG 301_ TCQVC 306_ RPGFF 311_ KASPH 316_ IQSCG 321_ KCPPH 326_ SYTHE 331_ EASTS 336_ CVCEK 341_ DYFRR 346_ ESDPP 351_ TMACT 356_ RPPSA 361_ PRNAI 366_ SNVNE 371_ TSVFL 376_ EWIPP 381_ ADTGG 386_ RKDVS 391_ YYIAC 396_ KKCNS 401_ HAGVC 406_ EECGG 411_ HVRYL 416_ PRQSG 421_ LKNTS 426_ VMMVD 431_ LLAHT 436_ NYTFE 441_ IEAVN 446_ GVSDL 451_ SPGAR 456_ QYVSV 461_ NVTTN 466_ QAAPS 471_ PVTNV 476_ KKGKI 481_ AKNSI 486_ SLSWQ 491_ EPDRP 496_ NGIIL 501_ EYEIK 506_ YFEKD 511_ QETSY 516_ TIIKS 521_ KETTI 526_ TAEGL 531_ KPASV 536_ YVFQI 541_ RARTA 546_ AGYGV 551_ FSRRF 556_ EFETT 561_ PVFAA 566_ SSDQS 571_ QIPVI 576_ AVSVT 581_ VGVIL 586_ LAVVI 591_ GVLLS 596_ GSCCE 601_ CGCGR 606_ ASSLC 611_ AVAHP 616_ SLIWR 621_ CGYSK 626_ AKQDP 631_ EEEKM 636_ HFHNG 641_ HIKLP 646_ GVRTY 651_ IDPHT 656_ YEDPN 661_ QAVHE 666_ FAKEI 671_ EASCI 676_ TIERV 681_ IGAGE 686_ FGEVC 691_ SGRLK 696_ LPGKR 701_ ELPVA 706_ IKTLK 711_ VGYTE 716_ KQRRD 721_ FLGEA 726_ SIMGQ 731_ FDHPN 736_ IIHLE 741_ GVVTK 746_ SKPVM 751_ IVTEY 756_ MENGS 761_ LDTFL 766_ KKNDG 771_ QFTVI 776_ QLVGM 781_ LRGIS 786_ AGMKY 791_ LSDMG 796_ YVHRD 801_ LAARN 806_ ILINS 811_ NLVCK 816_ VSDFG 821_ LSRVL 826_ EDDPE 831_ AAYTT 836_ RGGKI 841_ PIRWT 846_ APEAI 851_ AFRKF 856_ TSASD 861_ VWSYG 866_ IVMWE 871_ VVSYG 876_ ERPYW 881_ EMTNQ 886_ DVIKA 891_ VEEGY 896_ RLPSP 901_ MDCPA 906_ ALYQL 911_ MLDCW 916_ QKERN 921_ SRPKF 926_ DEIVN 931_ MLDKL 936_ IRNPS 941_ SLKTL 946_ VNASC 951_ RVSNL 956_ LAEHS 961_ PLGSG 966_ AYRSV 971_ GEWLE 976_ AIKMG 981_ RYTEI 986_ FMENG 991_ YSSMD 996_ AVAQV 1001_ TLEDL 1006_ RRLGV 1011_ TLVGH 1016_ QKKIM 1021_ NSLQE 1026_ MKVQL 1031_VNGMV
1: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity)