Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)
1_MELRV 6_ LLCWA 11_ SLAAA 16_ LEETL 21_ LNTKL 26_ ETADL 31_ KWVTF 36_ PQVDG 41_ QWEEL 46_ SGLDE 51_ EQHSV 56_ RTYEV 61_ CDVQR 66_ APGQA 71_ HWLRT 76_ GWVPR 81_ RGAVH 86_ VYATL 91_ RFTML 96_ ECLSL 101_ PRAGR 106_ SCKET 111_ FTVFY 116_ YESDA 121_ DTATA 126_ LTPAW 131_ MENPY 136_ IKVDT 141_ VAAEH 146_ LTRKR 151_ PGAEA 156_ TGKVN 161_ VKTLR 166_ LGPLS 171_ KAGFY 176_ LAFQD 181_ QGACM 186_ ALLSL 191_ HLFYK 196_ KCAQL 201_ TVNLT 206_ RFPET 211_ VPREL 216_ VVPVA 221_ GSCVV 226_ DAVPA 231_ PGPSP 236_ SLYCR 241_ EDGQW 246_ AEQPV 251_ TGCSC 256_ APGFE 261_ AAEGN 266_ TKCRA 271_ CAQGT 276_ FKPLS 281_ GEGSC 286_ QPCPA 291_ NSHSN 296_ TIGSA 301_ VCQCR 306_ VGYFR 311_ ARTDP 316_ RGAPC 321_ TTPPS 326_ APRSV 331_ VSRLN 336_ GSSLH 341_ LEWSA 346_ PLESG 351_ GREDL 356_ TYALR 361_ CRECR 366_ PGGSC 371_ APCGG 376_ DLTFD 381_ PGPRD 386_ LVEPW 391_ VVVRG 396_ LRPDF 401_ TYTFE 406_ VTALN 411_ GVSSL 416_ ATGPV 421_ PFEPV 426_ NVTTD 431_ REVPP 436_ AVSDI 441_ RVTRS 446_ SPSSL 451_ SLAWA 456_ VPRAP 461_ SGAVL 466_ DYEVK 471_ YHEKG 476_ AEGPS 481_ SVRFL 486_ KTSEN 491_ RAELR 496_ GLKRG 501_ ASYLV 506_ QVRAR 511_ SEAGY 516_ GPFGQ 521_ EHHSQ 526_ TQLDE 531_ SEGWR 536_ EQLAL 541_ IAGTA 546_ VVGVV 551_ LVLVV 556_ IVVAV 561_ LCLRK 566_ QSNGR 571_ EAEYS 576_ DKHGQ 581_ YLIGH 586_ GTKVY 591_ IDPFT 596_ YEDPN 601_ EAVRE 606_ FAKEI 611_ DVSYV 616_ KIEEV 621_ IGAGE 626_ FGEVC 631_ RGRLK 636_ APGKK 641_ ESCVA 646_ IKTLK 651_ GGYTE 656_ RQRRE 661_ FLSEA 666_ SIMGQ 671_ FEHPN 676_ IIRLE 681_ GVVTN 686_ SMPVM 691_ ILTEF 696_ MENGA 701_ LDSFL 706_ RLNDG 711_ QFTVI 716_ QLVGM 721_ LRGIA 726_ SGMRY 731_ LAEMS 736_ YVHRD 741_ LAARN 746_ ILVNS 751_ NLVCK 756_ VSDFG 761_ LSRFL 766_ EENSS 771_ DPTYT 776_ SSLGG 781_ KIPIR 786_ WTAPE 791_ AIAFR 796_ KFTSA 801_ SDAWS 806_ YGIVM 811_ WEVMS 816_ FGERP 821_ YWDMS 826_ NQDVI 831_ NAIEQ 836_ DYRLP 841_ PPPDC 846_ PTSLH 851_ QLMLD 856_ CWQKD 861_ RNARP 866_ RFPQV 871_ VSALD 876_ KMIRN 881_ PASLK 886_ IVARE 891_ NGGAS 896_ HPLLD 901_ QRQPH 906_ YSAFG 911_ SVGEW 916_ LRAIK 921_ MGRYE 926_ ESFAA 931_ AGFGS 936_ FELVS 941_ QISAE 946_ DLLRI 951_ GVTLA 956_ GHQKK 961_ ILASV 966_ QHMKS 971_ QAKPG 976_ TPGGT 981_GGPAP
1: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells