Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1)
1_MTSSY 6_ GHVLE 11_ RQPAL 16_ GGRLD 21_ SPGNL 26_ DTLQA 31_ KKNFS 36_ VSHLL 41_ DLEEA 46_ GDMVA 51_ AQADE 56_ NVGEA 61_ GRSLL 66_ ESPGL 71_ TSGSD 76_ TPQQD 81_ NDQLN 86_ SEEKK 91_ KRKQR 96_ RNRTT 101_ FNSSQ 106_ LQALE 111_ RVFER 116_ THYPD 121_ AFVRE 126_ DLARR 131_ VNLTE 136_ ARVQV 141_ WFQNR 146_ RAKFR 151_ RNERA 156_ MLANK 161_ NASLL 166_ KSYSG 171_ DVTAV 176_ EQPIV 181_ PRPAP 186_ RPTDY 191_ LSWGT 196_ ASPYS 201_ AMATY 206_ SATCA 211_ NNSPA 216_ QGINM 221_ ANSIA 226_ NLRLK 231_ AKEYS 236_LQRNQ
1: Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (PubMed:35589735). Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (By similarity)
2: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain
3: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines